ID   SLR_ECHML               Reviewed;          29 AA.
AC   P81798;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Snaclec multactivase regulatory subunit;
DE   Flags: Fragment;
OS   Echis multisquamatus (Central Asian sand viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Echis.
OX   NCBI_TaxID=93050 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=9443815; DOI=10.1093/oxfordjournals.jbchem.a021862;
RA   Yamada D., Morita T.;
RT   "Purification and characterization of a Ca2+ -dependent prothrombin
RT   activator, multactivase, from the venom of Echis multisquamatus.";
RL   J. Biochem. 122:991-997(1997).
CC   -!- FUNCTION: Multactivase, a carinactivase-like calcium-dependent
CC       prothrombin activator, activates prothrombin via recognition of the
CC       calcium ion bound conformation of its gamma-carboxyglutamic acid (GLA)
CC       domain, and the subsequent conversion of prothrombin to active thrombin
CC       is catalyzed by the catalytic subunit.
CC   -!- SUBUNIT: Heterodimer of a metalloproteinase subunit and a regulatory
CC       subunit comprising two homologous polypeptides disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR   PIR; PC4421; PC4421.
DR   AlphaFoldDB; P81798; -.
DR   SMR; P81798; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016504; F:peptidase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   1: Evidence at protein level;
KW   Blood coagulation cascade activating toxin; Calcium;
KW   Cell adhesion impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Hemostasis impairing toxin; Prothrombin activator; Secreted; Toxin.
FT   CHAIN           1..>29
FT                   /note="Snaclec multactivase regulatory subunit"
FT                   /id="PRO_0000078203"
FT   DOMAIN          1..>29
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        2..13
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   NON_TER         29
SQ   SEQUENCE   29 AA;  3458 MW;  DFCA64AD1BC22882 CRC64;
     DCLPGWSVYE GRCYKVFNQK TWKAAEKFC