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SLS1_YEAST
ID   SLS1_YEAST              Reviewed;         643 AA.
AC   P42900; D6VYD4; Q6B228;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Sigma-like sequence protein 1, mitochondrial;
DE            Short=Protein SLS1;
DE   Flags: Precursor;
GN   Name=SLS1; OrderedLocusNames=YLR139C; ORFNames=L3162;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=8917313; DOI=10.1007/bf02173976;
RA   Rouillard J.-M., Dufour M.-E., Theunissen B., Mandart E., Dujardin G.,
RA   Lacroute F.;
RT   "SLS1, a new Saccharomyces cerevisiae gene involved in mitochondrial
RT   metabolism, isolated as a syntheticlethal in association with an SSM4
RT   deletion.";
RL   Mol. Gen. Genet. 252:700-708(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   FUNCTION.
RX   PubMed=11805046; DOI=10.1093/genetics/160.1.75;
RA   Bryan A.C., Rodeheffer M.S., Wearn C.M., Shadel G.S.;
RT   "Sls1p is a membrane-bound regulator of transcription-coupled processes
RT   involved in Saccharomyces cerevisiae mitochondrial gene expression.";
RL   Genetics 160:75-82(2002).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Involved in aerobic respiration where it is required for
CC       assembly of respiratory chain enzyme complexes III and IV. Also has a
CC       role in mitochondrial gene expression. May be part of a mitochondrial
CC       membrane-associated RNA-shuttling system, delivering NAM1-associated
CC       transcripts to the translation machinery. {ECO:0000269|PubMed:11805046,
CC       ECO:0000269|PubMed:8917313}.
CC   -!- INTERACTION:
CC       P42900; P10849: MTF2; NbExp=3; IntAct=EBI-17364, EBI-11823;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000269|PubMed:8917313}.
CC   -!- MISCELLANEOUS: Present with 3430 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the SLS1 family. {ECO:0000305}.
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DR   EMBL; Z48452; CAA88362.1; -; Genomic_DNA.
DR   EMBL; X91258; CAA62658.1; -; Genomic_DNA.
DR   EMBL; Z73311; CAA97710.1; -; Genomic_DNA.
DR   EMBL; U53881; AAB82401.1; -; Genomic_DNA.
DR   EMBL; AY692902; AAT92921.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09450.1; -; Genomic_DNA.
DR   PIR; S55593; S55593.
DR   RefSeq; NP_013240.1; NM_001182026.1.
DR   AlphaFoldDB; P42900; -.
DR   BioGRID; 31408; 63.
DR   IntAct; P42900; 2.
DR   MINT; P42900; -.
DR   STRING; 4932.YLR139C; -.
DR   MaxQB; P42900; -.
DR   PaxDb; P42900; -.
DR   PRIDE; P42900; -.
DR   EnsemblFungi; YLR139C_mRNA; YLR139C; YLR139C.
DR   GeneID; 850830; -.
DR   KEGG; sce:YLR139C; -.
DR   SGD; S000004129; SLS1.
DR   VEuPathDB; FungiDB:YLR139C; -.
DR   eggNOG; ENOG502QUD1; Eukaryota.
DR   HOGENOM; CLU_390400_0_0_1; -.
DR   InParanoid; P42900; -.
DR   OMA; LWFELDE; -.
DR   BioCyc; YEAST:G3O-32279-MON; -.
DR   PRO; PR:P42900; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; P42900; protein.
DR   GO; GO:0016021; C:integral component of membrane; IDA:SGD.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR   GO; GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0009060; P:aerobic respiration; IMP:SGD.
DR   GO; GO:0032543; P:mitochondrial translation; IMP:SGD.
DR   InterPro; IPR032741; Sls1.
DR   Pfam; PF14611; SLS; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Protein biosynthesis; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..643
FT                   /note="Sigma-like sequence protein 1, mitochondrial"
FT                   /id="PRO_0000022360"
FT   REGION          43..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        103
FT                   /note="A -> V (in Ref. 4; AAT92921)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   643 AA;  73257 MW;  6CCD6FE80D669548 CRC64;
     MWKFNKKLAR LTYRLYSSSG PSSPLHGKKK LPQNLKFVVL NPTQSGLVKN DQKQPRHRPS
     KKRSHKETGD NNLDFGSKLL VFEKQNSLDS ALNSIRLKKP TSASLPSLEY NALLQSLTSS
     YNRYQLREFI STHQPDSSSH LTHWKKSKLS QYIIEKIWNC QPISTPTTPT GIKSTSLTFQ
     FDSPREIFLL LITQNGKILT NFNKLGLTFI ISIQDNELTV KGSPSLLKYA EISLNKIWSN
     ITHENVRMYS LMPSKDVINL IQKETHTFFE YLPDLQMYKI SALSTKKISM AKVFLLNAVA
     SNPNTTQHHH TIASPALKTE LYPFNNTLEN LDWLNKSQDW ARLQSVVPKN CTDLMTPTEN
     ATPELTDAQV SQFESSLSKN IPSLSPSDSI SQSLSITLGH SLQSASFSSI FQPLIHKSFI
     SKLLNLPMYK ESSSSAVPVP VPLDQHLITN AHQSFIQLNF TPVPPTSGSS SSPFLQIWFE
     IDEFDNIVTT SMRPLLKLQE NSVILRTPQC QTDYKITSDY IQDLLPDFDQ TNPDAWLSEQ
     KGLQEFLLKS HWKLNKYQNL MKKINISLPD NLIQQYQLTD VLTHRVLNLR FPTNTAQDDK
     YIIQYSDISR GFLNNGSYRQ LDFINVNPSE TSLKTFINDV LSF
 
 
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