SLT11_ASPFU
ID SLT11_ASPFU Reviewed; 383 AA.
AC Q4W9V0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Pre-mRNA-splicing factor slt11;
GN Name=slt11; ORFNames=AFUA_4G03640;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC formation of U2/U6 helix II in association with stem II in the
CC spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
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DR EMBL; AAHF01000016; EAL84513.1; -; Genomic_DNA.
DR RefSeq; XP_746551.1; XM_741458.1.
DR AlphaFoldDB; Q4W9V0; -.
DR SMR; Q4W9V0; -.
DR STRING; 746128.CADAFUBP00009659; -.
DR EnsemblFungi; EAL84513; EAL84513; AFUA_4G03640.
DR GeneID; 3504017; -.
DR KEGG; afm:AFUA_4G03640; -.
DR VEuPathDB; FungiDB:Afu4g03640; -.
DR eggNOG; KOG0153; Eukaryota.
DR HOGENOM; CLU_027112_1_0_1; -.
DR InParanoid; Q4W9V0; -.
DR OMA; PYFRKGR; -.
DR OrthoDB; 1272857at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12265; RRM_SLT11; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR039171; Cwc2/Slt11.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034356; Slt11_RRM.
DR PANTHER; PTHR14089; PTHR14089; 2.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW Spliceosome.
FT CHAIN 1..383
FT /note="Pre-mRNA-splicing factor slt11"
FT /id="PRO_0000212422"
FT DOMAIN 242..315
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 148..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 42471 MW; 76971FE04C2009FD CRC64;
MPPPQIKQDL NRSGWESTDF PSVCENCLPD NPYVQMLKED YGAECKICTR PFTIFRWKAD
RTARTKRTTI CLTCARLKNC CQCCMLDLSF GLPIVVRDAA LKMVAPGPES SINREYYAQE
HEKEIQEGRG AVEAYEKTDE KARELLRRLA NSEPYYRKPR QQLEGPSDDS TEAQPTDAPV
VQSRYGNGPG PIRTSESRRG TPLPGRGRGN MRGGRAGRPF PGTAQIPPSP EDYLPPADPN
IMSLFVTGVE DDLPEHTLRT FFTQFGQLRS LICSHRAHCA FINFATREGA EAAAQHCKGK
AVIQGCPLRV RWGKPKPLDN MDREERMKNA REGRLTVQAQ KDGESGQRAI TAAGEPATEK
PQSFVVAPPP GSGDVQYSSL SGD
