ID   SLT11_CANAL             Reviewed;         303 AA.
AC   Q5A5N5; A0A1D8PIS8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Pre-mRNA-splicing factor SLT11;
GN   Name=SLT11; Synonyms=ECM2; OrderedLocusNames=CAALFM_C210810WA;
GN   ORFNames=CaO19.12824, CaO19.5364;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC       formation of U2/U6 helix II in association with stem II in the
CC       spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW28048.1; -; Genomic_DNA.
DR   RefSeq; XP_717166.1; XM_712073.1.
DR   AlphaFoldDB; Q5A5N5; -.
DR   SMR; Q5A5N5; -.
DR   STRING; 237561.Q5A5N5; -.
DR   GeneID; 3641243; -.
DR   KEGG; cal:CAALFM_C210810WA; -.
DR   CGD; CAL0000189228; orf19.12824.
DR   VEuPathDB; FungiDB:C2_10810W_A; -.
DR   eggNOG; KOG0153; Eukaryota.
DR   HOGENOM; CLU_027112_1_1_1; -.
DR   InParanoid; Q5A5N5; -.
DR   OMA; RNVCQCC; -.
DR   OrthoDB; 1272857at2759; -.
DR   PRO; PR:Q5A5N5; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12265; RRM_SLT11; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039171; Cwc2/Slt11.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034356; Slt11_RRM.
DR   PANTHER; PTHR14089; PTHR14089; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW   Spliceosome.
FT   CHAIN           1..303
FT                   /note="Pre-mRNA-splicing factor SLT11"
FT                   /id="PRO_0000212423"
SQ   SEQUENCE   303 AA;  33876 MW;  192B1C276F38B6E4 CRC64;
     MSTDIFSICA KCLGDESRIK MIKQVNGDEC RQCTRPYTIY RWGNRKQGNK TIICITCARA
     RHCCQSCLLD ITYGIPTDLR DTALEMAGLE PLTKSANPTN REVKAIMADK LETKFKEQQE
     RSNDILSKLA EKLNKPEEKK TEVAIDVAKL AKKLPFGNSL DVQKYPDMTT FFVFGFSSDF
     PQAIFSRYAE QYGKVESVVF SSVSGCGFIR FEKVSSAVGF AKSIAENGLN KNKSIAGLLI
     LENTPMRVCF GKQKPLPRTA ADQRKLNTVV TKVMKQLASK SKVGVVVKTK PNVYKALSED
     YEE