SLT11_CANGA
ID SLT11_CANGA Reviewed; 364 AA.
AC Q6FKZ2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Pre-mRNA-splicing factor SLT11;
GN Name=SLT11; OrderedLocusNames=CAGL0L07458g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC formation of U2/U6 helix II in association with stem II in the
CC spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
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DR EMBL; CR380958; CAG62072.1; -; Genomic_DNA.
DR RefSeq; XP_449102.1; XM_449102.1.
DR AlphaFoldDB; Q6FKZ2; -.
DR SMR; Q6FKZ2; -.
DR STRING; 5478.XP_449102.1; -.
DR EnsemblFungi; CAG62072; CAG62072; CAGL0L07458g.
DR GeneID; 2890990; -.
DR KEGG; cgr:CAGL0L07458g; -.
DR CGD; CAL0136050; CAGL0L07458g.
DR VEuPathDB; FungiDB:CAGL0L07458g; -.
DR eggNOG; KOG0153; Eukaryota.
DR HOGENOM; CLU_027112_1_1_1; -.
DR InParanoid; Q6FKZ2; -.
DR OMA; RNVCQCC; -.
DR Proteomes; UP000002428; Chromosome L.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR CDD; cd12265; RRM_SLT11; 1.
DR InterPro; IPR039171; Cwc2/Slt11.
DR InterPro; IPR034356; Slt11_RRM.
DR PANTHER; PTHR14089; PTHR14089; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW Spliceosome.
FT CHAIN 1..364
FT /note="Pre-mRNA-splicing factor SLT11"
FT /id="PRO_0000212424"
FT REGION 339..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..364
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 41454 MW; EF619789BD2A4662 CRC64;
MNKLILGSEE VPQICEKCLG TSNTNENIRM NEVPNGAACK ICTLPYTLYH FKKSHRSADI
IKTLICKKCA IQRNVCQCCM LDMKLHISIQ LRDKLMSIVS GKETITEEAK NIMMKKFIAM
KGGSLGSADL TRNVDSIEDI LLNLREKLEG KPLNDENEPI SALQNKELGD NPHLKSVDIQ
PYWDKFPLQE TFPNAIQIPK GNDSFKSFFI YNIDSSVPEW KISDKITELL GSDSWKTKES
IPIIINHKAM CGAFRIGNNE LSEKFLQTIN NSDNMIRINR SNGLRRGILK VDHFQLFIIP
WKQGFSVESF GRTPNESKKI AFALREIIVE EMGGFKDKND RCKAKEKPKK ITKKSKKRVK
SIKI
