ID   SLT11_CRYNJ             Reviewed;         326 AA.
AC   P0CR50; Q55Z17; Q5KND3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Pre-mRNA-splicing factor SLT11;
GN   Name=SLT11; OrderedLocusNames=CNA06890;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC       formation of U2/U6 helix II in association with stem II in the
CC       spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
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DR   EMBL; AE017341; AAW41099.1; -; Genomic_DNA.
DR   RefSeq; XP_566918.1; XM_566918.1.
DR   AlphaFoldDB; P0CR50; -.
DR   SMR; P0CR50; -.
DR   STRING; 5207.AAW41099; -.
DR   PaxDb; P0CR50; -.
DR   EnsemblFungi; AAW41099; AAW41099; CNA06890.
DR   GeneID; 3253274; -.
DR   KEGG; cne:CNA06890; -.
DR   VEuPathDB; FungiDB:CNA06890; -.
DR   eggNOG; KOG0153; Eukaryota.
DR   HOGENOM; CLU_027112_0_0_1; -.
DR   InParanoid; P0CR50; -.
DR   OMA; PYFRKGR; -.
DR   OrthoDB; 1272857at2759; -.
DR   Proteomes; UP000002149; Chromosome 1.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039171; Cwc2/Slt11.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR032297; Torus.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   PANTHER; PTHR14089; PTHR14089; 1.
DR   Pfam; PF16131; Torus; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   RNA-binding; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..326
FT                   /note="Pre-mRNA-splicing factor SLT11"
FT                   /id="PRO_0000212425"
FT   ZN_FING         155..182
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ   SEQUENCE   326 AA;  35998 MW;  9C64676DB20568D3 CRC64;
     MPAKHDINKV GVESSDFPIL CETCLGPNPY VRMNKQEFGH ECKVCNRPFT VFRWNPGEGR
     MKKTEICTTC AKIKGVCQTC LLDLEFGLPT QVRDAALARK AQAPSSDINK QYYIQNLEAQ
     MAESPDGLAY DSEVANRAGR EMLKNLARTD PYYKRNRPHI CSFFVKGECK RGAECPFRHE
     MPKENETQKP SQQSLVDRYY GRNDPVAKKI LSQNAESKGL KAPEDKSITT LLFLGLPQCN
     DSHVRASLVG ACPFVKPSDV KSISIVEASH CAFVNFNQRS MAERAADALA AQGGIEVEGK
     KAKIVWGRAR PQKKAAAAVE GSAAPA