BICD1_MOUSE
ID BICD1_MOUSE Reviewed; 835 AA.
AC Q8BR07; O55206; Q8BQ18; Q8BRR8; Q8C4D3; Q8CAK6; Q8R2J4; Q8R2J5; Q8R2J6;
AC Q91YP7;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein bicaudal D homolog 1;
DE Short=Bic-D 1;
GN Name=Bicd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RC TISSUE=Brain, Brain cortex, Cerebellum, Hypothalamus, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 231-775 (ISOFORM 1).
RX PubMed=9367685; DOI=10.1006/geno.1997.4971;
RA Baens M., Marynen P.;
RT "A human homologue (BICD1) of the Drosophila bicaudal-D gene.";
RL Genomics 45:601-606(1997).
RN [4]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), INTERACTION WITH
RP CLIP-115 AND KIFC2, AND SUBCELLULAR LOCATION.
RA Hoogenraad C.C., Akhmanova A., Galjart N.;
RT "Mammalian BicD is a Golgi-associated protein that transiently interacts
RT with the neuronal proteins CLIP-115 and KIFC2.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates coat complex coatomer protein I (COPI)-independent
CC Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin
CC motor complex. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RAB6A. Interacts (via C-terminus) with RAB6B
CC (GTP-bound); the interaction is direct (By similarity). Interacts with
CC CLIP-115 and KIFC2. {ECO:0000250, ECO:0000269|Ref.4}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|Ref.4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8BR07-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BR07-2; Sequence=VSP_007965, VSP_007966;
CC Name=3;
CC IsoId=Q8BR07-3; Sequence=VSP_007967;
CC Name=4;
CC IsoId=Q8BR07-4; Sequence=VSP_007968;
CC -!- TISSUE SPECIFICITY: Expressed in the brain, heart and skeletal muscle.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryonic development.
CC -!- MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: Due to intron retention. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BicD family. {ECO:0000305}.
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DR EMBL; AK038585; BAC30057.1; -; mRNA.
DR EMBL; AK043650; BAC31607.1; -; mRNA.
DR EMBL; AK045975; BAC32557.1; -; mRNA.
DR EMBL; AK051718; BAC34733.1; -; mRNA.
DR EMBL; AK082523; BAC38518.1; -; mRNA.
DR EMBL; BC016192; AAH16192.1; -; mRNA.
DR EMBL; U90029; AAB94807.1; -; mRNA.
DR EMBL; AJ288054; CAC81709.1; -; mRNA.
DR EMBL; AJ288055; CAC81710.1; -; mRNA.
DR EMBL; AJ288056; CAC81711.1; -; mRNA.
DR CCDS; CCDS39723.1; -. [Q8BR07-1]
DR CCDS; CCDS51962.1; -. [Q8BR07-3]
DR RefSeq; NP_001106267.1; NM_001112796.2. [Q8BR07-3]
DR RefSeq; NP_033883.2; NM_009753.4. [Q8BR07-1]
DR PDB; 4YTD; X-ray; 1.50 A; A/B=711-808.
DR PDBsum; 4YTD; -.
DR AlphaFoldDB; Q8BR07; -.
DR SMR; Q8BR07; -.
DR BioGRID; 198348; 3.
DR IntAct; Q8BR07; 1.
DR STRING; 10090.ENSMUSP00000084039; -.
DR iPTMnet; Q8BR07; -.
DR PhosphoSitePlus; Q8BR07; -.
DR MaxQB; Q8BR07; -.
DR PaxDb; Q8BR07; -.
DR PRIDE; Q8BR07; -.
DR ProteomicsDB; 273684; -. [Q8BR07-1]
DR ProteomicsDB; 273685; -. [Q8BR07-2]
DR ProteomicsDB; 273686; -. [Q8BR07-3]
DR ProteomicsDB; 273687; -. [Q8BR07-4]
DR Antibodypedia; 24706; 65 antibodies from 22 providers.
DR DNASU; 12121; -.
DR Ensembl; ENSMUST00000086829; ENSMUSP00000084039; ENSMUSG00000003452. [Q8BR07-1]
DR Ensembl; ENSMUST00000111513; ENSMUSP00000107138; ENSMUSG00000003452. [Q8BR07-3]
DR GeneID; 12121; -.
DR KEGG; mmu:12121; -.
DR UCSC; uc009eug.3; mouse. [Q8BR07-2]
DR UCSC; uc009euh.3; mouse. [Q8BR07-1]
DR UCSC; uc009eui.3; mouse. [Q8BR07-3]
DR CTD; 636; -.
DR MGI; MGI:1101760; Bicd1.
DR VEuPathDB; HostDB:ENSMUSG00000003452; -.
DR eggNOG; KOG0999; Eukaryota.
DR GeneTree; ENSGT00940000154471; -.
DR HOGENOM; CLU_014107_1_0_1; -.
DR InParanoid; Q8BR07; -.
DR OrthoDB; 542877at2759; -.
DR TreeFam; TF323833; -.
DR Reactome; R-MMU-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 12121; 1 hit in 59 CRISPR screens.
DR ChiTaRS; Bicd1; mouse.
DR PRO; PR:Q8BR07; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BR07; protein.
DR Bgee; ENSMUSG00000003452; Expressed in sciatic nerve and 204 other tissues.
DR ExpressionAtlas; Q8BR07; baseline and differential.
DR Genevisible; Q8BR07; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISO:MGI.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0099503; C:secretory vesicle; ISO:MGI.
DR GO; GO:0005802; C:trans-Golgi network; ISO:MGI.
DR GO; GO:0008093; F:cytoskeletal anchor activity; ISO:MGI.
DR GO; GO:0034452; F:dynactin binding; ISO:MGI.
DR GO; GO:0070840; F:dynein complex binding; ISO:MGI.
DR GO; GO:0045505; F:dynein intermediate chain binding; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0031871; F:proteinase activated receptor binding; IPI:BHF-UCL.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR GO; GO:0072393; P:microtubule anchoring at microtubule organizing center; IMP:BHF-UCL.
DR GO; GO:0072385; P:minus-end-directed organelle transport along microtubule; ISO:MGI.
DR GO; GO:1900275; P:negative regulation of phospholipase C activity; IDA:BHF-UCL.
DR GO; GO:1900737; P:negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; IDA:BHF-UCL.
DR GO; GO:1904781; P:positive regulation of protein localization to centrosome; ISO:MGI.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISO:MGI.
DR GO; GO:0033365; P:protein localization to organelle; ISO:MGI.
DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; ISO:MGI.
DR GO; GO:1900276; P:regulation of proteinase activated receptor activity; IDA:BHF-UCL.
DR GO; GO:0034063; P:stress granule assembly; IMP:BHF-UCL.
DR GO; GO:0016032; P:viral process; ISO:MGI.
DR InterPro; IPR018477; BICD.
DR PANTHER; PTHR31233; PTHR31233; 1.
DR Pfam; PF09730; BicD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Golgi apparatus;
KW Reference proteome.
FT CHAIN 1..835
FT /note="Protein bicaudal D homolog 1"
FT /id="PRO_0000205358"
FT REGION 278..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..803
FT /note="Interaction with RAB6A"
FT /evidence="ECO:0000250"
FT REGION 800..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..264
FT /evidence="ECO:0000255"
FT COILED 320..519
FT /evidence="ECO:0000255"
FT COILED 663..803
FT /evidence="ECO:0000255"
FT COMPBIAS 567..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 195..210
FT /note="EYEGLKHEIKRFEEET -> RLKIFKKLYHRWIHMF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007965"
FT VAR_SEQ 211..835
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007966"
FT VAR_SEQ 821..835
FT /note="IVSSLLPPYRHSAHN -> SGHCPQ (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_007967"
FT VAR_SEQ 821..835
FT /note="IVSSLLPPYRHSAHN -> VSGEAPDTVPTIDTYLLHSQGPQIPTIRVSSGT
FT QRKRYACSYCHSVVQCTGFS (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_007968"
FT CONFLICT 70
FT /note="R -> K (in Ref. 4; CAC81709)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="D -> N (in Ref. 1; BAC34733)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="R -> Q (in Ref. 1; BAC38518)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="E -> K (in Ref. 1; BAC30057)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="H -> D (in Ref. 1; BAC32557)"
FT /evidence="ECO:0000305"
FT CONFLICT 470
FT /note="E -> K (in Ref. 3; AAB94807)"
FT /evidence="ECO:0000305"
FT CONFLICT 632
FT /note="I -> V (in Ref. 1; BAC32557)"
FT /evidence="ECO:0000305"
FT CONFLICT 796
FT /note="D -> G (in Ref. 4; CAC81711)"
FT /evidence="ECO:0000305"
FT HELIX 711..738
FT /evidence="ECO:0007829|PDB:4YTD"
FT HELIX 741..802
FT /evidence="ECO:0007829|PDB:4YTD"
FT HELIX 804..807
FT /evidence="ECO:0007829|PDB:4YTD"
SQ SEQUENCE 835 AA; 95896 MW; 33E8D83C56077C40 CRC64;
MAAEEALKTV DQYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ QYDELEAEYD
GLKQELEQLR EAFGQSFSIH RKVAEDGETR EETLLQESAS KEAYYLNKIL EMQNELKQSR
AVVTNVQAEN ERLSAVVQEL KENNEMVELQ RIRMKDEIRE YKFREARLLQ DYTELEEENI
TLQKLVSTLK QNQVEYEGLK HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN
EREQKNNLRK ELSQYINLSD SHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLGKLNGDY
RTPTTRKGES LHPVSDLFSE LNISEIQKLK QQLIQVEREK AILLANLQES QTQLEHTKGA
LTEQHERVHR LTEHVNAMRG LQNSKEIKAE LDCEKGRNSA EEAHDYEVDI NGLEILECKY
RVAVTEVIDL KAEIKALKEK YNKSVENYTE EKTKYESKIQ MYDEQVTNLE KTSKESGEKM
AHMEKELQKM TGIANENHNT LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ
SRVTRSGSLK GPDDPRGLLS PRLSRRGVSS PVESRTSSEP VSKENTETSK EPSPTKTPTI
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS RQRAAARELA
PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ TAEVALANLK NKYENEKAMV
TETMTKLRNE LKALKEDAAT FSSLRAMFAT RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL
RMAIQQKLAL TQRLEDLEFD HEQSRRSKGK LGKSKIGSPK IVSSLLPPYR HSAHN
