ID   SLT11_KLULA             Reviewed;         302 AA.
AC   Q6CJI0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Pre-mRNA-splicing factor SLT11;
GN   Name=SLT11; OrderedLocusNames=KLLA0F18502g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC       formation of U2/U6 helix II in association with stem II in the
CC       spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98617.1; -; Genomic_DNA.
DR   RefSeq; XP_455909.1; XM_455909.1.
DR   AlphaFoldDB; Q6CJI0; -.
DR   SMR; Q6CJI0; -.
DR   STRING; 28985.XP_455909.1; -.
DR   EnsemblFungi; CAG98617; CAG98617; KLLA0_F18502g.
DR   GeneID; 2895577; -.
DR   KEGG; kla:KLLA0_F18502g; -.
DR   eggNOG; KOG0153; Eukaryota.
DR   HOGENOM; CLU_027112_1_1_1; -.
DR   InParanoid; Q6CJI0; -.
DR   OMA; ARVACIT; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR013087; Znf_C2H2_type.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW   Spliceosome.
FT   CHAIN           1..302
FT                   /note="Pre-mRNA-splicing factor SLT11"
FT                   /id="PRO_0000212428"
FT   REGION          268..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  34579 MW;  6E6C4DC1DCC2AD3D CRC64;
     MSQDTGELKI CERCLPLGEN TPTLIRYPNG RECKFCTFPF DSYSYTINHT TFHTICCPKC
     ATKNLICQVC LNDFEHGIPM HLRNSMKQLL NENADSVIPK NDMMKRFIGL SSKQVAPLNI
     DKLKQAESIR KWRVRELPFN SNVNDTKDTF FLYNIDPNLT ESQIVSQLIV ATNNNLEREN
     TSLKLNSKLR IATLTFKQDP DLWTQKLISI LPKFKVGPTV EKCYLLMKGN RIHITSCLSD
     DFDVNNVNSE PEWDRLVQKI ITKDAKIIGT EPGKKKGKPK SGSKSDLHTK SKSSRRRHTL
     DL