ID   SLT11_NEUCR             Reviewed;         385 AA.
AC   Q7RUX3; Q9P3R0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Pre-mRNA-splicing factor slt-11;
GN   Name=slt-11; ORFNames=B24P7.250, NCU03007;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC       formation of U2/U6 helix II in association with stem II in the
CC       spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB97290.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL389890; CAB97290.2; ALT_INIT; Genomic_DNA.
DR   EMBL; CM002236; EAA36157.2; -; Genomic_DNA.
DR   RefSeq; XP_965393.2; XM_960300.3.
DR   AlphaFoldDB; Q7RUX3; -.
DR   SMR; Q7RUX3; -.
DR   STRING; 5141.EFNCRP00000002305; -.
DR   PRIDE; Q7RUX3; -.
DR   EnsemblFungi; EAA36157; EAA36157; NCU03007.
DR   GeneID; 3881543; -.
DR   KEGG; ncr:NCU03007; -.
DR   VEuPathDB; FungiDB:NCU03007; -.
DR   HOGENOM; CLU_027112_1_0_1; -.
DR   InParanoid; Q7RUX3; -.
DR   OMA; PYFRKGR; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12265; RRM_SLT11; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039171; Cwc2/Slt11.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034356; Slt11_RRM.
DR   PANTHER; PTHR14089; PTHR14089; 2.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW   Spliceosome.
FT   CHAIN           1..385
FT                   /note="Pre-mRNA-splicing factor slt-11"
FT                   /id="PRO_0000212429"
FT   DOMAIN          239..312
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          157..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..231
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  41285 MW;  A31537C7DC0572E7 CRC64;
     MPPQIKHDLN RSGWEATDFP SVCENCLPEN PYVKMLKEDY GAECKLCTRP FTVFSWAADR
     AHARKKRTNI CLTCARLKNA CQCCILDLQF GLPIIIRDKA LELVAPGPQS EINREYFAQN
     NERAIEEGRA GVEEYEKADE KARELLRRLA QSKPYFRKGR EVDEEGNPVN GSSSGAGRAT
     GGNPAVGAGV GGVGPIRTRD SRAAAAAGAR PGGGRRPNAA PAPPPGPKDW LPPADKSIMS
     LFVTGIEDDL PEFKIRDFFK AFGKIKSLVV SHMSHAAFVN YETREAAEKA SAECKGRAVI
     AGCPLRVRWS VPKALGTMNK EQRSEMLRDG RSAFGSGQKT GGQKAIGGQN AQGGASGAQK
     DDASNLTIAA PPGAADVQYA SLSGN