ID   SLT11_YARLI             Reviewed;         356 AA.
AC   Q6C3L4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Pre-mRNA-splicing factor SLT11;
GN   Name=SLT11; OrderedLocusNames=YALI0E33847g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC       formation of U2/U6 helix II in association with stem II in the
CC       spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG80353.1; -; Genomic_DNA.
DR   RefSeq; XP_504748.1; XM_504748.1.
DR   AlphaFoldDB; Q6C3L4; -.
DR   SMR; Q6C3L4; -.
DR   STRING; 4952.CAG80353; -.
DR   EnsemblFungi; CAG80353; CAG80353; YALI0_E33847g.
DR   GeneID; 2912833; -.
DR   KEGG; yli:YALI0E33847g; -.
DR   VEuPathDB; FungiDB:YALI0_E33847g; -.
DR   HOGENOM; CLU_027112_0_0_1; -.
DR   InParanoid; Q6C3L4; -.
DR   OMA; PYFRKGR; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12265; RRM_SLT11; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039171; Cwc2/Slt11.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034356; Slt11_RRM.
DR   PANTHER; PTHR14089; PTHR14089; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW   Spliceosome.
FT   CHAIN           1..356
FT                   /note="Pre-mRNA-splicing factor SLT11"
FT                   /id="PRO_0000212431"
FT   DOMAIN          223..298
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          321..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  38757 MW;  B06D85046ABDFF48 CRC64;
     MQTTKSDTNK ITWEDTEVPA VCTQCLGANP YIRMTKEKYG AECKMCTRPF TVFRWQPERA
     QKGSSRGKPL KTNVCLTCSR QKNCCQSCSL DLTYGLPLAI RDAALKMEQE GGGGGLSLSS
     SSNTITKQFI AQNYEEQLKQ DQRLLTDNSV TGTGKAQSAA KGLLKQLANA MPYRKELYEK
     GQKDKRPADS RDSKALTADV TKIASKLPLT GSTTPVPKDA SIKSLFFMGV EDDLPEHVIR
     KHFTETGGTI SLLTVVHRAH CGYVVFETRA AAEKAAAAIS GGRLVLNGCR LRVAWGKPRN
     LGSSSDEQWK LGQMIKKYLR SKGGSSNKDG AAGRDEAAPP PPGQGIKYQS QGNIEL