SLT3_CHLRE
ID SLT3_CHLRE Reviewed; 896 AA.
AC A8IHV3;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Probable sodium/sulfate cotransporter 3;
DE AltName: Full=SAC1-like transporter 3;
DE Short=CrSLT3;
GN Name=SLT3; ORFNames=CHLREDRAFT_205500;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP IDENTIFICATION, FUNCTION, AND INDUCTION BY SULFUR.
RX PubMed=20498339; DOI=10.1104/pp.110.157875;
RA Pootakham W., Gonzalez-Ballester D., Grossman A.R.;
RT "Identification and regulation of plasma membrane sulfate transporters in
RT Chlamydomonas.";
RL Plant Physiol. 153:1653-1668(2010).
CC -!- FUNCTION: Na(+)/sulfate cotransporter with a probable low-affinity for
CC sulfate. {ECO:0000269|PubMed:20498339}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Down-regulated by sulfur deprivation.
CC {ECO:0000269|PubMed:20498339}.
CC -!- SIMILARITY: Belongs to the divalent anion:Na+ symporter (DASS)
CC superfamily. Na+/sulfate symporter (TC 2.A.47.4) family. {ECO:0000305}.
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DR EMBL; DS496117; EDP05749.1; -; Genomic_DNA.
DR RefSeq; XP_001690490.1; XM_001690438.1.
DR AlphaFoldDB; A8IHV3; -.
DR STRING; 3055.EDP05749; -.
DR PaxDb; A8IHV3; -.
DR PRIDE; A8IHV3; -.
DR EnsemblPlants; PNW77628; PNW77628; CHLRE_10g445050v5.
DR GeneID; 5715971; -.
DR Gramene; PNW77628; PNW77628; CHLRE_10g445050v5.
DR eggNOG; ENOG502QPZM; Eukaryota.
DR HOGENOM; CLU_005170_6_0_1; -.
DR InParanoid; A8IHV3; -.
DR OrthoDB; 817305at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0008272; P:sulfate transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.1450; -; 4.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR Pfam; PF03600; CitMHS; 1.
DR Pfam; PF02080; TrkA_C; 4.
DR SUPFAM; SSF116726; SSF116726; 4.
DR PROSITE; PS51202; RCK_C; 4.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Repeat; Stress response; Sulfate transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..896
FT /note="Probable sodium/sulfate cotransporter 3"
FT /id="PRO_0000417126"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 685..705
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 734..754
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 804..824
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 212..296
FT /note="RCK C-terminal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT DOMAIN 319..404
FT /note="RCK C-terminal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT DOMAIN 408..493
FT /note="RCK C-terminal 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT DOMAIN 499..586
FT /note="RCK C-terminal 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT REGION 857..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 96679 MW; DF35C3E7D91E5C1D CRC64;
MAAIGWPGIV AIISVAISFI IMAADWVGPD ITFTILLSWL TAFDGKIITV AKAAAGYGNT
GLLTVIFLYW VAEGVTQTGG LELVMNYVLG RSRSVHWALV RSMFPVMVLS AFLNNTPCVT
FMIPILMSWA RRCGVPPKKL LIPLSYAAVL GGTCTSIGTS TNLVIVGMQD TRYNKQNKED
EAKFGMFDIA PYGVPYALMG FVFIILTQRF LLPGNSSRYA KDLLIAVRVL PSSPVVKKKL
KDSGLRTQTG FSLAGLWRGG AMTRQVDPDT VLEANDILYC AGELDVVEFV GEEFGLGLVT
AETERALTDG QAVGDSEATA FHDTGASPYK KLVQVTMTKT ADLVGRTVRE VSWQGRFGLI
PVAIQRGNGR EDGRLNDVVL AAGDVLILDT TPHFDEARDD FKINFEKLRF VKDGAAKEFV
IGVKVKKNSE VVNKTVTAAG LRGVPGLFVL SVDRADGSSV DASDYLYKIQ PGDTLWLAAD
VGAVGFLSKF PGLELVQQEQ VDKTGTSILY RHLVQAAVSH KGPLVGKTVR DVRFRTLYNA
AIVAVHREGV RVPLKVQDIV LQGGDVLLIS CHTKWAEEHR MDKAFVLVQA VPDSSPPKRG
RMAIGVLLVV GMVLTQIVGG LKEKEYIHLW PAAVLTAALM LLTGCMNADQ ARKAIMWDVY
LTIAAAFGVS AALENTGVAG KVANAIISIG KSIGGDGPAL IAIYVATAVM SELLTNNAAG
AIMYPIAAIA GDQLKIPAVD ISVAIMLGAS AGFINPFSYQ TNLMVYAAGN YSVREFATIG
APFQIWLMVV ASFILCYMKQ WKQVWIATWS ITAFIVFVPA LLTLLPHTVQ NRMEAFFDRI
AEAINPRAAL QRRRSARAQS FGGKAMSVGS TESRTDGSST PDVALTFIEM PKMGVR
