SLTM_XENLA
ID SLTM_XENLA Reviewed; 998 AA.
AC Q498L2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=SAFB-like transcription modulator;
GN Name=sltm;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a general inhibitor of transcription.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC100171; AAI00172.1; -; mRNA.
DR RefSeq; NP_001089646.1; NM_001096177.1.
DR AlphaFoldDB; Q498L2; -.
DR SMR; Q498L2; -.
DR PRIDE; Q498L2; -.
DR GeneID; 734706; -.
DR KEGG; xla:734706; -.
DR CTD; 734706; -.
DR Xenbase; XB-GENE-6255300; sltm.S.
DR OrthoDB; 803886at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 734706; Expressed in gastrula and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.720.30; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR034780; SLTM.
DR PANTHER; PTHR15683:SF5; PTHR15683:SF5; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR SUPFAM; SSF68906; SSF68906; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50800; SAP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; Repressor; RNA-binding;
KW Transcription; Transcription regulation.
FT CHAIN 1..998
FT /note="SAFB-like transcription modulator"
FT /id="PRO_0000307800"
FT DOMAIN 13..47
FT /note="SAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT DOMAIN 345..423
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 48..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 590..692
FT /evidence="ECO:0000255"
FT COMPBIAS 68..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..118
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 113131 MW; 420D98DF3D52330E CRC64;
MASSDTTTER KKLADLRVID LKTELKRRSL DVNGVKNVLM SRLKQAIEEE GGDPDNIELT
VNSDTPKKNS KNKGRKVEAD ESGCEASVEE DSGKDNELES QDVSDQDGND ELKDSEENEE
ESATFVNVLS TEEENETKQT SHFDNPERGS DIQAEEAEED EKKDVTGSGD VTQEISKPLH
SGDNESELRI KEEMETSTSL KEAEDDNVSV TIQAEDAITL DCDGDDLLET GKNVKIADSE
TSKPKDEQEA SYPKDGLEDQ KDLTSENQKD DKEESGKGDA VKKDGREASK KTESGDKDKD
SQKKGASSTG ASGQAKSSSK DAKESKSASK EDKGSTSSTS GSSTRNLWVS GLSSNTKAAD
LKNLFGKYGK VLSAKVVTNA RSPGAKCYGI VTMSSSADVA RCISHLHRTE LHGQQISVEK
VKNDPSKRDI KKDGDEKLGS GRTSGERKSS GGDKNSKTQS SVKKDDRRSS DKAEKKDGKE
LKKDSKEKSE SATTVPSPES SKKNEERKKP GGKSPGPMVV IDQTKGDQVY GRPPIRRGRF
DKMRNREPFF QNKMKFREFR DRKDILTFEK MKQQRIREKV ERMERIQRFR RAVEMRRSRE
MAERECRERE RIRIMREREE LDRLQRERER LEIERQKLER ERMERERLER ERIRIEQERR
REAERIARER EELRRQQEQL RFEQEKRNSL KRPRDVDHRR DEPFWNENKK MAVDTDSRFS
HGSDFNRQQN RFNDFDHRDR NRYSEGSNVS SFERRDRFVS PGEGKKGRPT MENFNKNFTD
SRRNEPAQPR NDPRDTDRRE VRDQDDRRPV GIERTGGNRN DGASHDRGRL GNPEIQHGRQ
RDSGNNQARS GTWKGEGGIS ADKREARGER TDRPTRESTG QPSRGGHASR GGKPGYTSRD
GDRSVIVGER GSSGQHFNEG RQVVERHGRD AGGPRKDWHA PSSQGSGYNA RRMSDGRSGG
MMSSNPAINR VVQMPGGSMQ RGSGSGFKSY KGAPQRRY
