SLU7A_ARATH
ID SLU7A_ARATH Reviewed; 535 AA.
AC Q9SHY8; O04483; Q84WT4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Pre-mRNA-splicing factor SLU7-A;
GN OrderedLocusNames=At1g65660; ORFNames=F1E22.4, F5I14.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Participates in the second catalytic step of pre-mRNA
CC splicing, when the free hydroxyl group of exon I attacks the 3'-splice
CC site to generate spliced mRNA and the excised lariat intron.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLU7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB60915.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF23844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC001229; AAB60915.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007234; AAF23844.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34408.1; -; Genomic_DNA.
DR EMBL; BT002797; AAO22622.1; -; mRNA.
DR PIR; E96681; E96681.
DR RefSeq; NP_564859.2; NM_105239.6.
DR AlphaFoldDB; Q9SHY8; -.
DR SMR; Q9SHY8; -.
DR STRING; 3702.AT1G65660.1; -.
DR iPTMnet; Q9SHY8; -.
DR PaxDb; Q9SHY8; -.
DR PRIDE; Q9SHY8; -.
DR ProteomicsDB; 232562; -.
DR EnsemblPlants; AT1G65660.1; AT1G65660.1; AT1G65660.
DR GeneID; 842877; -.
DR Gramene; AT1G65660.1; AT1G65660.1; AT1G65660.
DR KEGG; ath:AT1G65660; -.
DR Araport; AT1G65660; -.
DR TAIR; locus:2018496; AT1G65660.
DR eggNOG; KOG2560; Eukaryota.
DR HOGENOM; CLU_019317_3_1_1; -.
DR InParanoid; Q9SHY8; -.
DR OMA; KKPFYVD; -.
DR OrthoDB; 816947at2759; -.
DR PhylomeDB; Q9SHY8; -.
DR PRO; PR:Q9SHY8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHY8; baseline and differential.
DR Genevisible; Q9SHY8; AT.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030628; F:pre-mRNA 3'-splice site binding; IEA:InterPro.
DR GO; GO:0003727; F:single-stranded RNA binding; TAS:TAIR.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:TAIR.
DR GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR InterPro; IPR021715; Slu7_dom.
DR InterPro; IPR039974; Splicing_factor_SLU7.
DR PANTHER; PTHR12942; PTHR12942; 1.
DR Pfam; PF11708; Slu7; 1.
PE 1: Evidence at protein level;
KW Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Spliceosome; Zinc; Zinc-finger.
FT CHAIN 1..535
FT /note="Pre-mRNA-splicing factor SLU7-A"
FT /id="PRO_0000289203"
FT ZN_FING 94..111
FT /note="CCHC-type"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT CONFLICT 101
FT /note="A -> T (in Ref. 1; AAF23844)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 535 AA; 61978 MW; 5B6AC6A39F16A311 CRC64;
MATASVAFKS REDHRKQIEL EEARKAGLAP AEVDEDGKEI NPHIPQYMSS APWYLNSEKP
SLKHQRKWKS DPNYTKSWYD RGAKIFQAEK YRKGACQNCG AMTHTAKACM DRPRKIGAKY
TNMNIAPDEK IESFELDYDG KRDRWNGYDP STYHRVIDLY EAKEDARKKY LKEQQLKKLE
EKNNNEKGDD ANSDGEEDED DLRVDEAKVD ESRQMDFAKV EKRVRTTGGG STGTVRNLRI
REDTAKYLLN LDVNSAHYDP KTRSMREDPL PDADPNDKFY LGDNQYRNSG QALEFKQLNI
HSWEAFDKGQ DMHMQAAPSQ AELLYKSFQV AKEKLKSQTK DTIMDKYGNA ATEDEIPMEL
LLGQSERQVE YDRAGRIIKG QEVILPKSKY EEDVHANNHT SVWGSYWKDH QWGYKCCQQI
IRNSYCTGSA GIEAAEAALD LMKANIARKE ATEESPKKVE EKRMASWGTD IPEDLELNEE
ALANALKKED LSRREEKDER KRKYNVKYNN DVTPEEMEAY RMKRVHHEDP MKDFL
