ID   SLU7_CAEEL              Reviewed;         647 AA.
AC   Q21278;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Pre-mRNA-splicing factor SLU7;
GN   ORFNames=K07C5.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Participates in the second catalytic step of pre-mRNA
CC       splicing, when the free hydroxyl group of exon I attacks the 3'-splice
CC       site to generate spliced mRNA and the excised lariat intron.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLU7 family. {ECO:0000305}.
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DR   EMBL; Z71181; CAA94899.1; -; Genomic_DNA.
DR   PIR; T23407; T23407.
DR   RefSeq; NP_505661.1; NM_073260.4.
DR   AlphaFoldDB; Q21278; -.
DR   SMR; Q21278; -.
DR   BioGRID; 44473; 1.
DR   STRING; 6239.K07C5.6; -.
DR   iPTMnet; Q21278; -.
DR   EPD; Q21278; -.
DR   PaxDb; Q21278; -.
DR   PeptideAtlas; Q21278; -.
DR   PRIDE; Q21278; -.
DR   EnsemblMetazoa; K07C5.6.1; K07C5.6.1; WBGene00010629.
DR   GeneID; 179443; -.
DR   KEGG; cel:CELE_K07C5.6; -.
DR   UCSC; K07C5.6.1; c. elegans.
DR   CTD; 179443; -.
DR   WormBase; K07C5.6; CE06116; WBGene00010629; -.
DR   eggNOG; KOG2560; Eukaryota.
DR   GeneTree; ENSGT00390000002292; -.
DR   HOGENOM; CLU_019317_2_0_1; -.
DR   InParanoid; Q21278; -.
DR   OMA; KKPFYVD; -.
DR   OrthoDB; 555001at2759; -.
DR   PhylomeDB; Q21278; -.
DR   Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-CEL-72187; mRNA 3'-end processing.
DR   Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR   PRO; PR:Q21278; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00010629; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0030628; F:pre-mRNA 3'-splice site binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   InterPro; IPR021715; Slu7_dom.
DR   InterPro; IPR039974; Splicing_factor_SLU7.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR12942; PTHR12942; 1.
DR   Pfam; PF11708; Slu7; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   3: Inferred from homology;
KW   Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..647
FT                   /note="Pre-mRNA-splicing factor SLU7"
FT                   /id="PRO_0000289201"
FT   ZN_FING         113..130
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..479
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..532
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..552
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..605
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  74461 MW;  C506C0E13ACAF1CB CRC64;
     MASYKQNLPP SALIKQQVNV ADKKSKAEVQ RDRQLEEDRK AGTAPAMVDV QTGRDINPHI
     PMFISQNPWY VPSEGPTLKH QRPHEEREKK MTQIHEWYQK GTTGKSATKF RKGACENCGA
     MGHQKRDCFD RPRKSNAKET NDNIAEDDYV QPNLTLGFDA KRDRWNGYDP STHKQVIEDY
     EHLEEARKVV REHEMKEGEV EPATTEDGAP KDEDMYAEDA DMAGVSVDMD SRTRITVRNL
     RIREDTAKYL YNLAENSPYY DPKSRSMREN PFAGVAGKEL EAARFSGDNF VRYSGEVTAA
     NEAQVFAWQA TRGGVYAHSI AEPTKLEALK KEYEKEKSTL KNETQKELLD KYGGGEHMER
     PADELLLAQT ESYIEYNRKG KVIKGKEKVA ISSRFKEDIY PQNHTSVFGS FWREGRWGYK
     CCHQFVKNSY CTGKQGIEAE TSAAKGTTTS NEEIFKVPKL VEKTEVKEEK EKEDSIKDEV
     AEENSDNDND EEKEKVSEKS ISPSPPSDDE EKEKEREKER LIEKERRERD QRRRDKKREK
     RERKKAKLGK RKRRHRDSDD ESDPSSGSGS ESDSDEEMRK AMKKAKREKA EGMKAAREGD
     RGRKYNTDYS NTAPNEKEME AYRVTSVHSA DPMAAYMNSK FEKKHTK