ID   SLU7_CRYNB              Reviewed;         574 AA.
AC   P0CR53; Q55TV4; Q5KII3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Pre-mRNA-splicing factor SLU7;
GN   Name=SLU7; OrderedLocusNames=CNBD3490;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLU7 family. {ECO:0000305}.
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DR   EMBL; AAEY01000020; EAL21295.1; -; Genomic_DNA.
DR   RefSeq; XP_775942.1; XM_770849.1.
DR   AlphaFoldDB; P0CR53; -.
DR   SMR; P0CR53; -.
DR   EnsemblFungi; AAW43157; AAW43157; CND02870.
DR   EnsemblFungi; EAL21295; EAL21295; CNBD3490.
DR   GeneID; 4935738; -.
DR   KEGG; cnb:CNBD3490; -.
DR   VEuPathDB; FungiDB:CNBD3490; -.
DR   HOGENOM; CLU_019317_2_0_1; -.
DR   Proteomes; UP000001435; Chromosome 4.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030628; F:pre-mRNA 3'-splice site binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR021715; Slu7_dom.
DR   InterPro; IPR039974; Splicing_factor_SLU7.
DR   PANTHER; PTHR12942; PTHR12942; 1.
DR   Pfam; PF11708; Slu7; 1.
PE   3: Inferred from homology;
KW   Metal-binding; mRNA processing; mRNA splicing; Nucleus; Spliceosome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..574
FT                   /note="Pre-mRNA-splicing factor SLU7"
FT                   /id="PRO_0000410288"
FT   ZN_FING         100..117
FT                   /note="CCHC-type"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          481..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..225
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  65360 MW;  5BC1F23BB873BD6E CRC64;
     MLSTSTSLQG GKVSREEYRR QKDLEAARKA GTAPAALDEQ GNAINPHIPE YITKAPWYAD
     TGRPSLAHQR INEQGPHLKL DEWYDRGAKA GPAAKKYRKG ACENCGAMTH KMKDCVERPR
     KRGAKFTNKD IAPDELVQQF EGDYDAKRDR WNGYDPASYK HVVEEYEATE QMRKKYREEE
     IDQQTSTDMA VVKKLAKKDK EGKVEDDDDD FGSSDEDEDD EDKYADAADQ VGQKLDTKTR
     ITVRNLRIRE DTAKYLINLD ESSAYYDPKT RSMRDAPVRN MNPEDMKFAG DNFQRYSGDA
     TNMQKLQLFA WQSAQKGSNI NVSANPTAGE LLHREFQQKK EVLKDTNKTS ILAKYGGEEH
     LQRMPNELLS GQTENYVEYS RSGQIIKGRE RAKARSKYDE DVYINNHTAI WGSYYDLSTS
     QWGFACCHSV LPGSYCTGDA GKLANAASSA SALLASSNER SKIEEAAEKE RESLAEQHLK
     DLASGKAKKG KEREWDLPQY AKRREDGEEL DLDKGRLKNA LKEEKKRKKM GEDEAWQQTK
     KGKTDVTQEE LEAYRLSRQA YDDPMSNYQD PEDQ