ID   SLU7_DICDI              Reviewed;         558 AA.
AC   Q54TA0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Pre-mRNA-splicing factor slu7;
GN   Name=slu7; ORFNames=DDB_G0281901;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Participates in the second catalytic step of pre-mRNA
CC       splicing, when the free hydroxyl group of exon I attacks the 3'-splice
CC       site to generate spliced mRNA and the excised lariat intron.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLU7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000043; EAL66510.1; -; Genomic_DNA.
DR   RefSeq; XP_640489.1; XM_635397.1.
DR   AlphaFoldDB; Q54TA0; -.
DR   SMR; Q54TA0; -.
DR   STRING; 44689.DDB0233423; -.
DR   PaxDb; Q54TA0; -.
DR   EnsemblProtists; EAL66510; EAL66510; DDB_G0281901.
DR   GeneID; 8623303; -.
DR   KEGG; ddi:DDB_G0281901; -.
DR   dictyBase; DDB_G0281901; slu7.
DR   eggNOG; KOG2560; Eukaryota.
DR   HOGENOM; CLU_019317_2_0_1; -.
DR   InParanoid; Q54TA0; -.
DR   OMA; KKPFYVD; -.
DR   PhylomeDB; Q54TA0; -.
DR   PRO; PR:Q54TA0; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:dictyBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030628; F:pre-mRNA 3'-splice site binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   GO; GO:0000375; P:RNA splicing, via transesterification reactions; ISS:dictyBase.
DR   InterPro; IPR021715; Slu7_dom.
DR   InterPro; IPR039974; Splicing_factor_SLU7.
DR   PANTHER; PTHR12942; PTHR12942; 1.
DR   Pfam; PF11708; Slu7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..558
FT                   /note="Pre-mRNA-splicing factor slu7"
FT                   /id="PRO_0000331203"
FT   ZN_FING         94..111
FT                   /note="CCHC-type"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          474..514
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        428..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..522
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  64719 MW;  40B422EC0214C0BA CRC64;
     MASSISHRKT RDEYKKEKEL DEARKAGNAP AELDEEGKEI NPHIPEYILK APWYLNANKP
     SLKHQRGVTK KEMDKGWYLR GATTGEAATK FRKGACENCG AMTHKTKDCC ERPRKLGAKF
     TNDDIKPDEV IQKLELDYDS KRDPYNGYDP SSYKEVMDIY EKADTERKKK KLQELIKQHG
     GGGDKKTPDV DETLSKELMD NEEKEGSYDS ETVAPIQKLD QKSRTTIRNL RIREDTAKYL
     YNLDVNSAFY EPKSRSMRDN PLPNANPNDI KFAGDNFART SGETKEFRDL QRFAWEAQEK
     GQDVDISSAP SQAALLHADF LRKKEQLKQQ TRNQLLTKYG GEEHLLKQEE IDKVPQSEIY
     TEYSSSGKLI KGEEKIVKSK YEEDVFLNNH KSIWGSYWEN GQWGFACCRQ LIKNAYCTGE
     KGKLLREKQL QQQQQHHIQQ ENQQDDDDNN TTTTTTTTTT SLLEQHLNKS NEDNDKHNKK
     EGKRKDKKER KEKEEKLKKA LKDQDEENKK SVEKDERNIK YNSLSADDYN VSEEQMEAYN
     LKRKRSDDPM ANFKDDSD