ID   SLU7_KLULA              Reviewed;         341 AA.
AC   Q6CK06;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Pre-mRNA-splicing factor SLU7;
GN   Name=SLU7; OrderedLocusNames=KLLA0F14531g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLU7 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98441.1; -; Genomic_DNA.
DR   RefSeq; XP_455733.1; XM_455733.1.
DR   AlphaFoldDB; Q6CK06; -.
DR   STRING; 28985.XP_455733.1; -.
DR   PRIDE; Q6CK06; -.
DR   EnsemblFungi; CAG98441; CAG98441; KLLA0_F14531g.
DR   GeneID; 2894988; -.
DR   KEGG; kla:KLLA0_F14531g; -.
DR   eggNOG; KOG2560; Eukaryota.
DR   HOGENOM; CLU_072877_0_0_1; -.
DR   InParanoid; Q6CK06; -.
DR   OMA; KSKMFRR; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0030628; F:pre-mRNA 3'-splice site binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR021715; Slu7_dom.
DR   InterPro; IPR039974; Splicing_factor_SLU7.
DR   PANTHER; PTHR12942; PTHR12942; 1.
DR   Pfam; PF11708; Slu7; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..341
FT                   /note="Pre-mRNA-splicing factor SLU7"
FT                   /id="PRO_0000218549"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  38953 MW;  D00CAFF6095E9C80 CRC64;
     MRRGNSGARG NRGGSRGKPG QNEHIPNFIK NKPWYLAEES EVSASTSAIN SNSTISGTGT
     GTGTELEEKD YLSHHRLKKS SVPDSGTAEI DDAFTYVRPS GRNRKKKDSY DLDLDAPVRR
     RDEKVIESNY DAKRDRWYGY TPDIKEIERN HKGPDTSHRE MDEVQIQEME RLGLKPEDVG
     FDATQPLSGP KEKYNPVRLR EDKAAYLQDM SSEEMLYDPK SRIYKSKEEG TIDPKSKMFH
     RHLTGDALQV GVINERVRQE AVRSGIKDFE VNKEKLNHVF AANPTKYELM MRTEPERKQE
     TSVEQDAAPK RRKFDKNSFK ESSSSSNPGS STMKDLYDKY M