BICL1_DANRE
ID BICL1_DANRE Reviewed; 569 AA.
AC P0CF95;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 1.
DT 03-AUG-2022, entry version 34.
DE RecName: Full=BICD family-like cargo adapter 1;
DE AltName: Full=Bicaudal D-related protein 1;
DE Short=BICD-related protein 1;
DE Short=BICDR-1;
DE AltName: Full=Coiled-coil domain-containing protein 64A;
GN Name=bicdl1; Synonyms=bicdr1, ccdc64;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20360680; DOI=10.1038/emboj.2010.51;
RA Schlager M.A., Kapitein L.C., Grigoriev I., Burzynski G.M., Wulf P.S.,
RA Keijzer N., de Graaff E., Fukuda M., Shepherd I.T., Akhmanova A.,
RA Hoogenraad C.C.;
RT "Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related
RT protein 1 (BICDR-1) regulates neuritogenesis.";
RL EMBO J. 29:1637-1651(2010).
CC -!- FUNCTION: Component of secretory vesicle machinery in developing
CC neurons that acts as a regulator of neurite outgrowth.
CC {ECO:0000269|PubMed:20360680}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Note=Localizes around the centrosome.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in developing neural tissues and
CC developing eye. {ECO:0000269|PubMed:20360680}.
CC -!- SIMILARITY: Belongs to the BICDR family. {ECO:0000305}.
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DR PRIDE; P0CF95; -.
DR ZFIN; ZDB-GENE-091204-439; bicdl1.
DR InParanoid; P0CF95; -.
DR PRO; PR:P0CF95; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0034452; F:dynactin binding; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0031076; P:embryonic camera-type eye development; IMP:ZFIN.
DR GO; GO:0001654; P:eye development; IMP:UniProtKB.
DR GO; GO:0055107; P:Golgi to secretory granule transport; ISS:UniProtKB.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IGI:ZFIN.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0047496; P:vesicle transport along microtubule; IGI:ZFIN.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Neurogenesis; Reference proteome;
KW Transport.
FT CHAIN 1..569
FT /note="BICD family-like cargo adapter 1"
FT /id="PRO_0000394263"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..283
FT /evidence="ECO:0000255"
FT COILED 458..520
FT /evidence="ECO:0000255"
SQ SEQUENCE 569 AA; 65461 MW; EAA9F163FEAC5C8D CRC64;
MSASCLDLIS APPQPDSDRM DRALNPGRQN SPDTAGELTL LHTAPGGLGM ALEEELAMLT
GDREDELQES APETPVSGQD SDLLSLFRQK EKDLVLAAKL GKALLERNQD LTKQYDKMTK
DLNDRLELLE QEKHELRRRL ESREGEWEGR VAELETDVQH LQGELERHQL QLRDADREKS
RAISELSEQN HRLLEQLSRA AEVEKQLSTQ VHSLRDDFKE KSISSNQHMT RLETLQAEIR
MLSERKQDLE RRVCAVLEEN QQLQNTVEEL RERTLELEKH CHHKDLQKIL PETLLTIIKL
KTNYSQKKKK TEHLILHTRR AHTHLCRAPS EVQSCMGSLS CVWCIQRRKD CDLFLLQLRL
QLWEAYCQVR SICSQLRGND ITDSALSTDS SMDESSETLS AKDVPTGSLH SSLLELRRLT
QNLLDGNEST VALLSVEVSS SREENERLRA MTEVHEPNEQ LQSAIRDRDE AIAKKKAVEM
ELAKCKIDIM SLNSBQLLDA IQQKLNLSQQ LEAWQDDMHR VIDQQLMDKH QEEWKDPPFS
FSRRGAAASR PTQRLADRDK PLFSFFKKN
