ID   SLUR2_MACMU             Reviewed;          97 AA.
AC   P0DP61; F6VEA7; F6VEB6; F6VED0; P61050;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Secreted Ly-6/uPAR domain-containing protein 2 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=SLURP2 {ECO:0000250|UniProtKB:P0DP58};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RA   Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.;
RT   "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA
RT   sequences.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds and may modulate the functional properties of nicotinic
CC       and muscarinic acetylcholine receptors. May regulate keratinocytes
CC       proliferation, differentiation and apoptosis. In vitro moderately
CC       inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs,
CC       strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-
CC       containing nAChRs, and inhibits nicotine-induced signaling probably
CC       implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-
CC       3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as
CC       CHRM1 and CHRM3, in an allosteric manner.
CC       {ECO:0000250|UniProtKB:P0DP57}.
CC   -!- SUBUNIT: Interacts with CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB2 and
CC       CHRNB4. Interacts with CHRM1 and CHRM3 probably in an allosteric manner
CC       (By similarity). {ECO:0000250|UniProtKB:P0DP57}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DP57}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JV045600; AFI35671.1; -; mRNA.
DR   RefSeq; NP_001253551.1; NM_001266622.2.
DR   AlphaFoldDB; P0DP61; -.
DR   SMR; P0DP61; -.
DR   Ensembl; ENSMMUT00000021016; ENSMMUP00000019652; ENSMMUG00000041404.
DR   GeneID; 100428508; -.
DR   KEGG; mcc:100428508; -.
DR   CTD; 432355; -.
DR   VEuPathDB; HostDB:ENSMMUG00000041404; -.
DR   GeneTree; ENSGT00940000153378; -.
DR   OrthoDB; 1544318at2759; -.
DR   Proteomes; UP000006718; Chromosome 8.
DR   Bgee; ENSMMUG00000041404; Expressed in dorsolateral prefrontal cortex and 22 other tissues.
DR   ExpressionAtlas; P0DP61; baseline.
DR   GO; GO:0031225; C:anchored component of membrane; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0033130; F:acetylcholine receptor binding; ISS:UniProtKB.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR   GO; GO:0030548; F:acetylcholine receptor regulator activity; ISS:UniProtKB.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0099601; P:regulation of neurotransmitter receptor activity; ISS:UniProtKB.
DR   CDD; cd00117; LU; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..97
FT                   /note="Secreted Ly-6/uPAR domain-containing protein 2"
FT                   /id="PRO_0000036156"
FT   DOMAIN          23..95
FT                   /note="UPAR/Ly6"
FT   DISULFID        25..47
FT                   /evidence="ECO:0000250|UniProtKB:P0DP57"
FT   DISULFID        28..34
FT                   /evidence="ECO:0000250|UniProtKB:P0DP57"
FT   DISULFID        40..68
FT                   /evidence="ECO:0000250|UniProtKB:P0DP57"
FT   DISULFID        72..88
FT                   /evidence="ECO:0000250|UniProtKB:P0DP57"
FT   DISULFID        89..94
FT                   /evidence="ECO:0000250|UniProtKB:P0DP57"
SQ   SEQUENCE   97 AA;  10275 MW;  67347EAB23A4F00F CRC64;
     MQFHTGLLLA AVLSLQLAAA QALWCHQCTG FGGCSRGSRC PRDSTHCVTT ATRVLSNIEN
     LPLVTKMCHT GCPDIPSLGL GPYVSIACCQ TSLCNHD