BICL1_HUMAN
ID BICL1_HUMAN Reviewed; 573 AA.
AC Q6ZP65; A8MUC8; B4DWL0; B5MDJ0; O95000;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=BICD family-like cargo adapter 1;
DE AltName: Full=Bicaudal D-related protein 1;
DE Short=BICD-related protein 1;
DE Short=BICDR-1;
DE AltName: Full=Coiled-coil domain-containing protein 64A;
DE Short=CCDC64A;
GN Name=BICDL1; Synonyms=BICDR1, CCDC64;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- FUNCTION: Component of secretory vesicle machinery in developing
CC neurons that acts as a regulator of neurite outgrowth. Regulates the
CC secretory vesicle transport by controlling the accumulation of Rab6-
CC containing secretory vesicles in the pericentrosomal region restricting
CC anterograde secretory transport during the early phase of neuronal
CC differentiation, thereby inhibiting neuritogenesis (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KIF1C. Interacts with RAB6A and RAB6B;
CC interaction is specific to Rab6 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Note=Localizes around the centrosome.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZP65-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZP65-2; Sequence=VSP_056941, VSP_056942;
CC -!- SIMILARITY: Belongs to the BICDR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC83181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC85259.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR EMBL; AK129960; BAC85259.1; ALT_SEQ; mRNA.
DR EMBL; AK301580; BAG63072.1; -; mRNA.
DR EMBL; AC004812; AAC83181.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC004815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41845.1; -. [Q6ZP65-1]
DR RefSeq; NP_997194.2; NM_207311.2. [Q6ZP65-1]
DR AlphaFoldDB; Q6ZP65; -.
DR SMR; Q6ZP65; -.
DR BioGRID; 124955; 1.
DR IntAct; Q6ZP65; 2.
DR STRING; 9606.ENSP00000380690; -.
DR iPTMnet; Q6ZP65; -.
DR PhosphoSitePlus; Q6ZP65; -.
DR BioMuta; BICDL1; -.
DR DMDM; 313104078; -.
DR jPOST; Q6ZP65; -.
DR MassIVE; Q6ZP65; -.
DR PaxDb; Q6ZP65; -.
DR PeptideAtlas; Q6ZP65; -.
DR PRIDE; Q6ZP65; -.
DR ProteomicsDB; 5351; -.
DR ProteomicsDB; 68060; -. [Q6ZP65-1]
DR Antibodypedia; 62366; 25 antibodies from 8 providers.
DR DNASU; 92558; -.
DR Ensembl; ENST00000397558.6; ENSP00000380690.2; ENSG00000135127.12. [Q6ZP65-1]
DR GeneID; 92558; -.
DR KEGG; hsa:92558; -.
DR UCSC; uc001txl.2; human. [Q6ZP65-1]
DR CTD; 92558; -.
DR GeneCards; BICDL1; -.
DR HGNC; HGNC:28095; BICDL1.
DR HPA; ENSG00000135127; Tissue enhanced (kidney, pituitary gland, retina).
DR MIM; 617002; gene.
DR neXtProt; NX_Q6ZP65; -.
DR OpenTargets; ENSG00000135127; -.
DR PharmGKB; PA143485416; -.
DR VEuPathDB; HostDB:ENSG00000135127; -.
DR eggNOG; ENOG502QUA9; Eukaryota.
DR GeneTree; ENSGT00940000157442; -.
DR HOGENOM; CLU_029068_0_0_1; -.
DR InParanoid; Q6ZP65; -.
DR OMA; IDMHELI; -.
DR OrthoDB; 595515at2759; -.
DR PhylomeDB; Q6ZP65; -.
DR TreeFam; TF326671; -.
DR PathwayCommons; Q6ZP65; -.
DR SignaLink; Q6ZP65; -.
DR SIGNOR; Q6ZP65; -.
DR BioGRID-ORCS; 92558; 14 hits in 1072 CRISPR screens.
DR ChiTaRS; BICDL1; human.
DR GenomeRNAi; 92558; -.
DR Pharos; Q6ZP65; Tdark.
DR PRO; PR:Q6ZP65; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6ZP65; protein.
DR Bgee; ENSG00000135127; Expressed in metanephros cortex and 158 other tissues.
DR ExpressionAtlas; Q6ZP65; baseline and differential.
DR Genevisible; Q6ZP65; HS.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0034452; F:dynactin binding; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0055107; P:Golgi to secretory granule transport; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Neurogenesis;
KW Reference proteome; Transport.
FT CHAIN 1..573
FT /note="BICD family-like cargo adapter 1"
FT /id="PRO_0000302858"
FT REGION 67..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..376
FT /evidence="ECO:0000255"
FT COILED 440..525
FT /evidence="ECO:0000255"
FT COMPBIAS 386..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..351
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056941"
FT VAR_SEQ 436
FT /note="T -> TGSRRLDDDSLEEQIRQTSEDSRALRELMEGERGKLRQSLEELQRLH
FT SQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056942"
FT CONFLICT 79..97
FT /note="Missing (in Ref. 1; BAC85259)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 64841 MW; F514AF0264B13F09 CRC64;
MSAFCLGLVG RASAPAEPDS ACCMELPAAA GDAVRSPAAA AALIFPGGSG ELELALEEEL
ALLAAGERPS DPGEHPQAEP GSLAEGAGPQ PPPSQDPELL SVIRQKEKDL VLAARLGKAL
LERNQDMSRQ YEQMHKELTD KLEHLEQEKH ELRRRFENRE GEWEGRVSEL ESDVKQLQDE
LERQQIHLRE ADREKSRAVQ ELSEQNQRLL DQLSRASEVE RQLSMQVHAL REDFREKNSS
TNQHIIRLES LQAEIKMLSD RKRELEHRLS ATLEENDLLQ GTVEELQDRV LILERQGHDK
DLQLHQSQLE LQEVRLSCRQ LQVKVEELTE ERSLQSSAAT STSLLSEIEQ SMEAEELEQE
REQLRLQLWE AYCQVRYLCS HLRGNDSADS AVSTDSSMDE SSETSSAKDV PAGSLRTALN
ELKRLIQSIV DGMEPTVTLL SVEMTALKEE RDRLRVTSED KEPKEQLQKA IRDRDEAIAK
KNAVELELAK CRMDMMSLNS QLLDAIQQKL NLSQQLEAWQ DDMHRVIDRQ LMDTHLKERS
QPAAALCRGH SAGRGDEPSI AEGKRLFSFF RKI
