BICL1_MOUSE
ID BICL1_MOUSE Reviewed; 577 AA.
AC A0JNT9; Q8C9J5; Q8CB56; Q8R1D2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=BICD family-like cargo adapter 1;
DE AltName: Full=Bicaudal D-related protein 1;
DE Short=BICD-related protein 1;
DE Short=BICDR-1;
DE AltName: Full=Coiled-coil domain-containing protein 64A;
GN Name=Bicdl1; Synonyms=Bicdr1, Ccdc64;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH KIF1C;
RP RAB6A AND RAB6B, AND MUTAGENESIS OF LYS-512.
RX PubMed=20360680; DOI=10.1038/emboj.2010.51;
RA Schlager M.A., Kapitein L.C., Grigoriev I., Burzynski G.M., Wulf P.S.,
RA Keijzer N., de Graaff E., Fukuda M., Shepherd I.T., Akhmanova A.,
RA Hoogenraad C.C.;
RT "Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related
RT protein 1 (BICDR-1) regulates neuritogenesis.";
RL EMBO J. 29:1637-1651(2010).
CC -!- FUNCTION: Component of secretory vesicle machinery in developing
CC neurons that acts as a regulator of neurite outgrowth. Regulates the
CC secretory vesicle transport by controlling the accumulation of Rab6-
CC containing secretory vesicles in the pericentrosomal region restricting
CC anterograde secretory transport during the early phase of neuronal
CC differentiation, thereby inhibiting neuritogenesis.
CC {ECO:0000269|PubMed:20360680}.
CC -!- SUBUNIT: Interacts with KIF1C. Interacts with RAB6A and RAB6B;
CC interaction is specific to Rab6. {ECO:0000269|PubMed:20360680}.
CC -!- INTERACTION:
CC A0JNT9; P35279: Rab6a; NbExp=6; IntAct=EBI-7893170, EBI-444674;
CC A0JNT9; P61294: Rab6b; NbExp=2; IntAct=EBI-7893170, EBI-529766;
CC A0JNT9; O43896: KIF1C; Xeno; NbExp=3; IntAct=EBI-7893170, EBI-1644048;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:20360680}. Note=Localizes around
CC the centrosome.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A0JNT9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0JNT9-2; Sequence=VSP_027971, VSP_027973;
CC Name=3;
CC IsoId=A0JNT9-3; Sequence=VSP_027970, VSP_027972, VSP_027974,
CC VSP_027975;
CC -!- TISSUE SPECIFICITY: Highly expressed during early embryonic
CC development. Predominantly expressed in kidney, undifferentiated neural
CC tissue and developing eye. {ECO:0000269|PubMed:20360680}.
CC -!- DEVELOPMENTAL STAGE: Predominately expressed in early developing
CC neurons before the stage of neurite outgrowth and elongation. Then,
CC expression strongly declines during neuronal development.
CC -!- SIMILARITY: Belongs to the BICDR family. {ECO:0000305}.
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DR EMBL; AK036757; BAC29565.1; -; mRNA.
DR EMBL; AK041990; BAC31124.1; -; mRNA.
DR EMBL; BC024804; AAH24804.1; -; mRNA.
DR EMBL; BC126948; AAI26949.1; -; mRNA.
DR CCDS; CCDS39230.1; -. [A0JNT9-1]
DR RefSeq; NP_001074277.1; NM_001080808.1. [A0JNT9-1]
DR PDB; 6F1T; EM; 3.50 A; X/x=1-325.
DR PDB; 6F1U; EM; 3.40 A; X/x=1-577.
DR PDB; 6ZNM; EM; 4.10 A; X/x=1-325.
DR PDBsum; 6F1T; -.
DR PDBsum; 6F1U; -.
DR PDBsum; 6ZNM; -.
DR AlphaFoldDB; A0JNT9; -.
DR SMR; A0JNT9; -.
DR BioGRID; 217656; 8.
DR IntAct; A0JNT9; 18.
DR MINT; A0JNT9; -.
DR STRING; 10090.ENSMUSP00000053547; -.
DR iPTMnet; A0JNT9; -.
DR PhosphoSitePlus; A0JNT9; -.
DR EPD; A0JNT9; -.
DR PaxDb; A0JNT9; -.
DR PRIDE; A0JNT9; -.
DR ProteomicsDB; 273610; -. [A0JNT9-1]
DR ProteomicsDB; 273611; -. [A0JNT9-2]
DR ProteomicsDB; 273612; -. [A0JNT9-3]
DR Antibodypedia; 62366; 25 antibodies from 8 providers.
DR Ensembl; ENSMUST00000055408; ENSMUSP00000053547; ENSMUSG00000041609. [A0JNT9-1]
DR GeneID; 75665; -.
DR KEGG; mmu:75665; -.
DR UCSC; uc008zel.1; mouse. [A0JNT9-1]
DR UCSC; uc008zem.1; mouse. [A0JNT9-3]
DR CTD; 92558; -.
DR MGI; MGI:1922915; Bicdl1.
DR VEuPathDB; HostDB:ENSMUSG00000041609; -.
DR eggNOG; ENOG502QUA9; Eukaryota.
DR GeneTree; ENSGT00940000157442; -.
DR HOGENOM; CLU_029068_0_0_1; -.
DR InParanoid; A0JNT9; -.
DR OMA; IDMHELI; -.
DR OrthoDB; 595515at2759; -.
DR PhylomeDB; A0JNT9; -.
DR TreeFam; TF326671; -.
DR BioGRID-ORCS; 75665; 7 hits in 74 CRISPR screens.
DR ChiTaRS; Bicdl1; mouse.
DR PRO; PR:A0JNT9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; A0JNT9; protein.
DR Bgee; ENSMUSG00000041609; Expressed in retinal neural layer and 164 other tissues.
DR ExpressionAtlas; A0JNT9; baseline and differential.
DR Genevisible; A0JNT9; MM.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0034452; F:dynactin binding; IDA:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; IDA:UniProtKB.
DR GO; GO:0055107; P:Golgi to secretory granule transport; IMP:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; IMP:UniProtKB.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Neurogenesis; Reference proteome; Transport.
FT CHAIN 1..577
FT /note="BICD family-like cargo adapter 1"
FT /id="PRO_0000302859"
FT REGION 63..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..379
FT /evidence="ECO:0000255"
FT COILED 443..528
FT /evidence="ECO:0000255"
FT COMPBIAS 84..100
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..240
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027970"
FT VAR_SEQ 1..227
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027971"
FT VAR_SEQ 241..257
FT /note="NSSTNQHIIRLESLQAE -> MLSQLNSTPSCGSPSFQ (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027972"
FT VAR_SEQ 307..577
FT /note="LHQSQLELQEVRLSYRQLQGKVEELTEERSLQSSAATSTSLLSEIEQSMEAE
FT ELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGS
FT LRTALNDLKRLIQSIVDGVEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRD
FT RDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLM
FT DTHLKEQSRPAAAAFPRGHGVGRGQEPSTADGKRLFSFFRKI -> ESQVHASGSVSAK
FT PRKILGFLILSKEISCQSKGHSAPYRSV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027973"
FT VAR_SEQ 440..509
FT /note="VTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELEL
FT AKCKMDMMSLNSQLLDAI -> STRRMDDDSLEEQIRQTSEDSRALRELMEGERGKLRQ
FT SLEELQQLHSQVSTPVSQCRECARGLYLMRPPV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027974"
FT VAR_SEQ 510..577
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027975"
FT MUTAGEN 512
FT /note="K->M: Abolishes Rab6-binding."
FT /evidence="ECO:0000269|PubMed:20360680"
FT CONFLICT 124
FT /note="L -> S (in Ref. 2; AAH24804)"
FT /evidence="ECO:0000305"
FT HELIX 133..209
FT /evidence="ECO:0007829|PDB:6F1U"
SQ SEQUENCE 577 AA; 65287 MW; DD6326D93D663D07 CRC64;
MSAFCLGLAG RASAPAEPDS ACCMELPAGA GDAVRSPATA AALVSFPGGP GELELALEEE
LALLAAGERS SEPGEHPQAE PESPVEGHGP PLPPPPTQDP ELLSVIRQKE KDLVLAARLG
KALLERNQDM SRQYEQMHKE LTDKLEHLEQ EKHELRRRFE NREGEWEGRV SELETDVKQL
QDELERQQLH LREADREKTR AVQELSEQNQ RLLDQLSRAS EVERQLSMQV HALKEDFREK
NSSTNQHIIR LESLQAEIKM LSDRKRELEH RLSATLEEND LLQGTVEELQ DRVLILERQG
HDKDLQLHQS QLELQEVRLS YRQLQGKVEE LTEERSLQSS AATSTSLLSE IEQSMEAEEL
EQEREQLRLQ LWEAYCQVRY LCSHLRGNDS ADSAVSTDSS MDESSETSSA KDVPAGSLRT
ALNDLKRLIQ SIVDGVEPTV TLLSVEMTAL KEERDRLRVT SEDKEPKEQL QKAIRDRDEA
IAKKNAVELE LAKCKMDMMS LNSQLLDAIQ QKLNLSQQLE AWQDDMHRVI DRQLMDTHLK
EQSRPAAAAF PRGHGVGRGQ EPSTADGKRL FSFFRKI
