ID   SLX1_BRUMA              Reviewed;         333 AA.
AC   A8PV03;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Structure-specific endonuclease subunit SLX1 homolog {ECO:0000255|HAMAP-Rule:MF_03100};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_03100};
GN   ORFNames=Bm1_35165;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: Catalytic subunit of a heterodimeric structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03100}.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_03100};
CC   -!- SUBUNIT: Forms a heterodimer with a member of the SLX4 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03100}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03100}.
CC   -!- SIMILARITY: Belongs to the SLX1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03100}.
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DR   EMBL; DS239406; EDP32696.1; -; Genomic_DNA.
DR   RefSeq; XP_001898482.1; XM_001898447.1.
DR   AlphaFoldDB; A8PV03; -.
DR   SMR; A8PV03; -.
DR   STRING; 6279.A8PV03; -.
DR   PRIDE; A8PV03; -.
DR   EnsemblMetazoa; Bm4448a.1; Bm4448a.1; WBGene00224709.
DR   GeneID; 6101922; -.
DR   KEGG; bmy:BM_BM4448; -.
DR   WBParaSite; Bm4448a.1; Bm4448a.1; WBGene00224709.
DR   CTD; 6101922; -.
DR   WormBase; Bm4448a; BM01626; WBGene00224709; Bma-slx-1.
DR   HOGENOM; CLU_030739_0_0_1; -.
DR   InParanoid; A8PV03; -.
DR   OMA; LQFEHAW; -.
DR   OrthoDB; 1171480at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0048257; F:3'-flap endonuclease activity; IEA:EnsemblMetazoa.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:EnsemblMetazoa.
DR   GO; GO:0008821; F:crossover junction endodeoxyribonuclease activity; IEA:EnsemblMetazoa.
DR   GO; GO:0019899; F:enzyme binding; IEA:EnsemblMetazoa.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblMetazoa.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblMetazoa.
DR   GO; GO:0002164; P:larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0000706; P:meiotic DNA double-strand break processing; IEA:EnsemblMetazoa.
DR   GO; GO:0061064; P:negative regulation of nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0040019; P:positive regulation of embryonic development; IEA:EnsemblMetazoa.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:EnsemblMetazoa.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_03100; Endonuc_su_Slx1; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR027520; Slx1.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Endonuclease; Hydrolase;
KW   Metal-binding; Nuclease; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..333
FT                   /note="Structure-specific endonuclease subunit SLX1
FT                   homolog"
FT                   /id="PRO_0000383749"
FT   DOMAIN          68..157
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03100"
FT   ZN_FING         237..293
FT                   /note="SLX1-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03100"
SQ   SEQUENCE   333 AA;  38248 MW;  782A592BC21D8A9D CRC64;
     MSADESNIIC IEDDEENIEE SGVKYSDKLP VCQGSSKILC RSSSQEVIQE NERKKRGKNY
     AVPSILDDFF GVYCLLSRSP NRYFKNRCYI GYTVNPNRRI RQHNAGKEFG GAKKTDHRGP
     WDMVCIIHGF PNSVSALRFE WAWQNPEKSR RLRLLNLKKR TSETAFGFRL RIACHMLNSD
     PWRRLSLTFR WLLPELEIPF PLDVLPPSHI AVEHGAVTKI STLIPQLQEE YDVAGTCSLC
     LKPILSISEL LRCHANETCK SHFHMRCLSK HALNAVDEYR TSLFPIQGQC PKCGVVYLWG
     DLIRDQRILL AVNKFNSSST LFNMIPRGKL IKM