BICL2_HUMAN
ID BICL2_HUMAN Reviewed; 508 AA.
AC A1A5D9; Q658L9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=BICD family-like cargo adapter 2;
DE AltName: Full=Bicaudal D-related protein 2;
DE Short=BICD-related protein 2;
DE Short=BICDR-2;
DE AltName: Full=Coiled-coil domain-containing protein 64B;
GN Name=BICDL2; Synonyms=BICDR2, CCDC64B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-273.
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLU-55 AND
RP ARG-273.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with RAB13. {ECO:0000250}.
CC -!- INTERACTION:
CC A1A5D9; Q9BZZ5-2: API5; NbExp=3; IntAct=EBI-10171799, EBI-10989614;
CC A1A5D9; Q00537: CDK17; NbExp=3; IntAct=EBI-10171799, EBI-624648;
CC A1A5D9; Q6P597: KLC3; NbExp=4; IntAct=EBI-10171799, EBI-1643885;
CC A1A5D9; Q6P597-3: KLC3; NbExp=3; IntAct=EBI-10171799, EBI-12076930;
CC A1A5D9; Q13835-2: PKP1; NbExp=3; IntAct=EBI-10171799, EBI-9087684;
CC A1A5D9; P32969: RPL9P9; NbExp=3; IntAct=EBI-10171799, EBI-358122;
CC A1A5D9; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-10171799, EBI-10241197;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A1A5D9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1A5D9-2; Sequence=VSP_027976;
CC -!- SIMILARITY: Belongs to the BICDR family. {ECO:0000305}.
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DR EMBL; AL833749; CAH56245.1; -; mRNA.
DR EMBL; AC108134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128602; AAI28603.1; -; mRNA.
DR CCDS; CCDS45393.1; -. [A1A5D9-1]
DR RefSeq; NP_001096645.1; NM_001103175.1. [A1A5D9-1]
DR RefSeq; XP_005255192.1; XM_005255135.4. [A1A5D9-1]
DR AlphaFoldDB; A1A5D9; -.
DR SMR; A1A5D9; -.
DR BioGRID; 126987; 10.
DR IntAct; A1A5D9; 6.
DR STRING; 9606.ENSP00000459043; -.
DR GlyGen; A1A5D9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A1A5D9; -.
DR PhosphoSitePlus; A1A5D9; -.
DR BioMuta; BICDL2; -.
DR EPD; A1A5D9; -.
DR jPOST; A1A5D9; -.
DR MassIVE; A1A5D9; -.
DR PaxDb; A1A5D9; -.
DR PeptideAtlas; A1A5D9; -.
DR PRIDE; A1A5D9; -.
DR ProteomicsDB; 117; -. [A1A5D9-1]
DR ProteomicsDB; 118; -. [A1A5D9-2]
DR Antibodypedia; 52456; 31 antibodies from 11 providers.
DR DNASU; 146439; -.
DR Ensembl; ENST00000389347.4; ENSP00000373998.4; ENSG00000162069.16. [A1A5D9-1]
DR Ensembl; ENST00000572449.6; ENSP00000459043.1; ENSG00000162069.16. [A1A5D9-1]
DR Ensembl; ENST00000573514.5; ENSP00000461724.1; ENSG00000162069.16. [A1A5D9-2]
DR GeneID; 146439; -.
DR KEGG; hsa:146439; -.
DR MANE-Select; ENST00000572449.6; ENSP00000459043.1; NM_001369667.1; NP_001356596.1.
DR UCSC; uc002cte.5; human. [A1A5D9-1]
DR CTD; 146439; -.
DR DisGeNET; 146439; -.
DR GeneCards; BICDL2; -.
DR HGNC; HGNC:33584; BICDL2.
DR HPA; ENSG00000162069; Tissue enhanced (esophagus, pancreas).
DR MIM; 617003; gene.
DR neXtProt; NX_A1A5D9; -.
DR OpenTargets; ENSG00000162069; -.
DR PharmGKB; PA162381686; -.
DR VEuPathDB; HostDB:ENSG00000162069; -.
DR eggNOG; ENOG502QRVU; Eukaryota.
DR GeneTree; ENSGT00940000160797; -.
DR HOGENOM; CLU_924265_0_0_1; -.
DR InParanoid; A1A5D9; -.
DR OrthoDB; 595515at2759; -.
DR PhylomeDB; A1A5D9; -.
DR TreeFam; TF326671; -.
DR PathwayCommons; A1A5D9; -.
DR SignaLink; A1A5D9; -.
DR BioGRID-ORCS; 146439; 60 hits in 1065 CRISPR screens.
DR GenomeRNAi; 146439; -.
DR Pharos; A1A5D9; Tdark.
DR PRO; PR:A1A5D9; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A1A5D9; protein.
DR Bgee; ENSG00000162069; Expressed in lower esophagus mucosa and 128 other tissues.
DR ExpressionAtlas; A1A5D9; baseline and differential.
DR Genevisible; A1A5D9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:GOC.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0055107; P:Golgi to secretory granule transport; IBA:GO_Central.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..508
FT /note="BICD family-like cargo adapter 2"
FT /id="PRO_0000302861"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..300
FT /evidence="ECO:0000255"
FT COILED 353..458
FT /evidence="ECO:0000255"
FT COMPBIAS 138..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..207
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027976"
FT VARIANT 55
FT /note="Q -> E (in dbSNP:rs7204908)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060543"
FT VARIANT 273
FT /note="Q -> R (in dbSNP:rs2244494)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_034978"
SQ SEQUENCE 508 AA; 56834 MW; A3E6222CF0B2473E CRC64;
MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL ALQLQQKEKD
LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN HELRRGLAAR GAEWEARAVE
LEGDVEALRA QLGEQRSEQQ DSGRERARAL SELSEQNLRL SQQLAQASQT EQELQRELDA
LRGQCQAQAL AGAELRTRLE SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE
LLLLRRERRE HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA
HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL SPAEILEEKE
VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL HSALSDRDEA VNKALELSLQ
LNRVSLERDS LSRELLRAIR QKVALTQELE AWQDDMQVVI GQQLRSQRQK ELSASASSST
PRRAAPRFSL RLGPGPAGGF LSNLFRRT
