BICL2_MOUSE
ID BICL2_MOUSE Reviewed; 507 AA.
AC Q8CHW5; Q8CB50;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=BICD family-like cargo adapter 2;
DE AltName: Full=Bicaudal D-related protein 2;
DE Short=BICD-related protein 2;
DE Short=BICDR-2;
DE AltName: Full=Coiled-coil domain-containing protein 64B;
GN Name=Bicdl2; Synonyms=Bicdr2, Ccdc64b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH RAB13.
RX PubMed=20360680; DOI=10.1038/emboj.2010.51;
RA Schlager M.A., Kapitein L.C., Grigoriev I., Burzynski G.M., Wulf P.S.,
RA Keijzer N., de Graaff E., Fukuda M., Shepherd I.T., Akhmanova A.,
RA Hoogenraad C.C.;
RT "Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related
RT protein 1 (BICDR-1) regulates neuritogenesis.";
RL EMBO J. 29:1637-1651(2010).
CC -!- SUBUNIT: Interacts with RAB13. {ECO:0000269|PubMed:20360680}.
CC -!- SIMILARITY: Belongs to the BICDR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29578.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK133729; BAE21806.1; -; mRNA.
DR EMBL; AK036793; BAC29578.1; ALT_INIT; mRNA.
DR EMBL; BC038613; AAH38613.1; -; mRNA.
DR CCDS; CCDS28453.1; -.
DR RefSeq; NP_722479.1; NM_153784.3.
DR AlphaFoldDB; Q8CHW5; -.
DR SMR; Q8CHW5; -.
DR BioGRID; 229355; 16.
DR IntAct; Q8CHW5; 11.
DR MINT; Q8CHW5; -.
DR STRING; 10090.ENSMUSP00000053808; -.
DR iPTMnet; Q8CHW5; -.
DR PhosphoSitePlus; Q8CHW5; -.
DR PaxDb; Q8CHW5; -.
DR PRIDE; Q8CHW5; -.
DR ProteomicsDB; 273744; -.
DR Antibodypedia; 52456; 31 antibodies from 11 providers.
DR DNASU; 212733; -.
DR Ensembl; ENSMUST00000062967; ENSMUSP00000053808; ENSMUSG00000043782.
DR Ensembl; ENSMUST00000232760; ENSMUSP00000156752; ENSMUSG00000043782.
DR GeneID; 212733; -.
DR KEGG; mmu:212733; -.
DR UCSC; uc008asr.1; mouse.
DR CTD; 146439; -.
DR MGI; MGI:2388267; Bicdl2.
DR VEuPathDB; HostDB:ENSMUSG00000043782; -.
DR eggNOG; ENOG502QRVU; Eukaryota.
DR GeneTree; ENSGT00940000160797; -.
DR HOGENOM; CLU_029068_2_1_1; -.
DR InParanoid; Q8CHW5; -.
DR OMA; QSEIAHS; -.
DR OrthoDB; 595515at2759; -.
DR PhylomeDB; Q8CHW5; -.
DR TreeFam; TF326671; -.
DR BioGRID-ORCS; 212733; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q8CHW5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8CHW5; protein.
DR Bgee; ENSMUSG00000043782; Expressed in dorsal pancreas and 60 other tissues.
DR ExpressionAtlas; Q8CHW5; baseline and differential.
DR Genevisible; Q8CHW5; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:GOC.
DR GO; GO:0031267; F:small GTPase binding; IDA:UniProtKB.
DR GO; GO:0055107; P:Golgi to secretory granule transport; IBA:GO_Central.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..507
FT /note="BICD family-like cargo adapter 2"
FT /id="PRO_0000302862"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..292
FT /evidence="ECO:0000255"
FT COILED 354..459
FT /evidence="ECO:0000255"
FT COMPBIAS 324..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 57527 MW; 6AA98B44FA2501F2 CRC64;
MDSPGEPSFP SGLLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL ALQLQQKEKD
LLLAAELGKM LLERNEELRR QLETLNTQHL EHEERLQQEN HELRRGLAAR GAEWEARAVE
LEGDVEALRA QLGEQRSERQ DSGRERARAL GELSEQNLRL SQQLAQASRT EQELQRELDT
LRERCQTQAL AGAELGARLE SLQAENQMLQ DRRQDLEAQI RGLREEVDKG QNRLQTTHEE
LLLLRRERKE HKLELERARF EAGEALRTLR GLQRRVSELE EESRLQDTEI SGASLQTELA
HSLDSDQDQD QQVNECGGSQ AILSPETQET SSPQPSIQEE ILEPPKKRAS LSPVEILEEK
EAEVARLQDE ITLHRTELQT LRDELQRQKE LRAQDNPEEA LSSALSDRDE AVNKAMKLSL
ELSRVSLERD SLSRELLRAI RQKVALTQEL EAWQDDMQVV IGQQLRSQRQ KELSEAAAAP
RRAKTRFSLR LGSGQSGGFL SNLFRRT
