ID   SLX41_CANTT             Reviewed;         714 AA.
AC   C5M2G0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4 1 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=SLX4-1 {ECO:0000255|HAMAP-Rule:MF_03110}; ORFNames=CTRG_00249;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EER35510.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG692395; EER35510.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_002545468.1; XM_002545422.1.
DR   AlphaFoldDB; C5M2G0; -.
DR   SMR; C5M2G0; -.
DR   EnsemblFungi; EER35510; EER35510; CTRG_00249.
DR   GeneID; 8297249; -.
DR   KEGG; ctp:CTRG_00249; -.
DR   eggNOG; ENOG502RS18; Eukaryota.
DR   HOGENOM; CLU_429039_0_0_1; -.
DR   OrthoDB; 1409030at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..714
FT                   /note="Structure-specific endonuclease subunit SLX4 1"
FT                   /id="PRO_0000388023"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..90
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  79606 MW;  EBE26F48D9119542 CRC64;
     MSPEGEESHA EDNLYFHNTQ MQSIHEETLA EESHAQSIQR SISRLSSFKH EDTDSESPIP
     VQKVIRHIKK TNTNTNTTKT KKRKLKVSKP RKNMSSSESV RQMYGSRKNG EQQGSIDGFL
     MSRFGDVDGC NESDRSSKLI SQGEWESLSK FHEESNEKDK LLRKKIQRYY SEPQEELGEG
     CGMLSQASAD PETKMTKEEL ESLYDLDSST VFNQTTISAI GDMSEPTQVS EPCVVILSQT
     KVQSEASTQE DGADASVQEI KSSVPTQELF STPEFVPAPL EQPVNKEVCS DQSIVVLEEN
     VQSTQADDSD IVELISDSDP EPEEVSTKVQ VLRSIYDSSG PVNDKQPSVA SETVESDSTP
     IVSPVKTPQG TRMHVVQVAS SNPSSPIKIV EENTEQQEEV FTDVESIYST ARTSFGTPKH
     TSPVILLESS DTDCDDNDND VEPLSSMPMV KTVPKKRMRT TVLQVSAALK VQNYTDEKNN
     IKLRKIGDDI PVEVPTKDVE YEEIPDSQES VGGEGDNSVS IIEITREVHN NDYTGDESTD
     LFQVGLNKQD TCEDTSSPVV QIGGVENDIL DSSLIEPVPE PESVPVPEEV QEQPQPTAID
     KHTATQLREK FQLWGLKPVR GKEKMVEILQ GISNFILPEH ELLAVADKQE LQSCIFMKLD
     AVIREGRAMY DRILSFEPIR IEELQMMLQS QDYYLELDVL RLYCDSSGIT TTNA