SLX4I_MOUSE
ID SLX4I_MOUSE Reviewed; 413 AA.
AC Q9D7Y9; Q6NXK0; Q9CWT7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein SLX4IP;
DE AltName: Full=SLX4-interacting protein;
GN Name=Slx4ip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Egg, Embryonic stem cell, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with SLX4/BTBD12; subunit of different structure-
CC specific endonucleases. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D7Y9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D7Y9-2; Sequence=VSP_028421;
CC Name=3;
CC IsoId=Q9D7Y9-3; Sequence=VSP_028422, VSP_028423;
CC -!- SIMILARITY: Belongs to the SLX4IP family. {ECO:0000305}.
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DR EMBL; AK008687; BAB25833.1; -; mRNA.
DR EMBL; AK010392; BAB26906.1; -; mRNA.
DR EMBL; AK136226; BAE22883.1; -; mRNA.
DR EMBL; AL713981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL731706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067037; AAH67037.1; -; mRNA.
DR EMBL; BC071202; AAH71202.1; -; mRNA.
DR CCDS; CCDS16795.1; -. [Q9D7Y9-1]
DR CCDS; CCDS16796.1; -. [Q9D7Y9-2]
DR RefSeq; NP_001033730.1; NM_001038641.1. [Q9D7Y9-1]
DR RefSeq; NP_082477.1; NM_028201.2. [Q9D7Y9-2]
DR RefSeq; NP_083110.1; NM_028834.2. [Q9D7Y9-1]
DR RefSeq; XP_006500353.1; XM_006500290.3. [Q9D7Y9-2]
DR RefSeq; XP_006500356.1; XM_006500293.3.
DR RefSeq; XP_011238113.1; XM_011239811.1. [Q9D7Y9-1]
DR AlphaFoldDB; Q9D7Y9; -.
DR STRING; 10090.ENSMUSP00000096914; -.
DR iPTMnet; Q9D7Y9; -.
DR PhosphoSitePlus; Q9D7Y9; -.
DR EPD; Q9D7Y9; -.
DR jPOST; Q9D7Y9; -.
DR MaxQB; Q9D7Y9; -.
DR PaxDb; Q9D7Y9; -.
DR PeptideAtlas; Q9D7Y9; -.
DR PRIDE; Q9D7Y9; -.
DR ProteomicsDB; 261427; -. [Q9D7Y9-1]
DR ProteomicsDB; 261428; -. [Q9D7Y9-2]
DR Antibodypedia; 62780; 27 antibodies from 7 providers.
DR Ensembl; ENSMUST00000028737; ENSMUSP00000028737; ENSMUSG00000027281. [Q9D7Y9-2]
DR Ensembl; ENSMUST00000099311; ENSMUSP00000096914; ENSMUSG00000027281. [Q9D7Y9-1]
DR Ensembl; ENSMUST00000180277; ENSMUSP00000136131; ENSMUSG00000027281. [Q9D7Y9-1]
DR GeneID; 74243; -.
DR KEGG; mmu:74243; -.
DR UCSC; uc008mou.1; mouse. [Q9D7Y9-2]
DR UCSC; uc008mov.1; mouse. [Q9D7Y9-3]
DR UCSC; uc008mow.1; mouse. [Q9D7Y9-1]
DR CTD; 128710; -.
DR MGI; MGI:1921493; Slx4ip.
DR VEuPathDB; HostDB:ENSMUSG00000027281; -.
DR eggNOG; ENOG502QQHZ; Eukaryota.
DR GeneTree; ENSGT00390000016400; -.
DR HOGENOM; CLU_039900_0_0_1; -.
DR InParanoid; Q9D7Y9; -.
DR OMA; GIHLRCI; -.
DR OrthoDB; 575561at2759; -.
DR PhylomeDB; Q9D7Y9; -.
DR TreeFam; TF330769; -.
DR BioGRID-ORCS; 74243; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Slx4ip; mouse.
DR PRO; PR:Q9D7Y9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D7Y9; protein.
DR Bgee; ENSMUSG00000027281; Expressed in animal zygote and 165 other tissues.
DR ExpressionAtlas; Q9D7Y9; baseline and differential.
DR Genevisible; Q9D7Y9; MM.
DR InterPro; IPR031479; SLX4IP.
DR PANTHER; PTHR28557; PTHR28557; 1.
DR Pfam; PF15744; UPF0492; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..413
FT /note="Protein SLX4IP"
FT /id="PRO_0000306120"
FT REGION 172..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 389
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 61
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 79
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 167
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 176
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 236
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 288
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 344
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 353
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT CROSSLNK 396
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VYV7"
FT VAR_SEQ 40..135
FT /note="EVCLLLKETIDSRVKEYVGIYKQRKPSSAEFTRSSPLSLKGYGFQITAYFLK
FT RGIHLHCIQNSQNTELRVFPERFVVCVSQLAFGHDIWANQNEKS -> VMAFRSQLISS
FT REGYTFTVSRTPRIL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028421"
FT VAR_SEQ 40..125
FT /note="EVCLLLKETIDSRVKEYVGIYKQRKPSSAEFTRSSPLSLKGYGFQITAYFLK
FT RGIHLHCIQNSQNTELRVFPERFVVCVSQLAFGH -> VMAFRSQLISSREGYTFTVSR
FT TPRILNFVYFLKDLWCVLVSLHLVMIFGQTRMKNRQKKPSMECLIIFLSVQRVHRLLVQ
FT SSRGTL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028422"
FT VAR_SEQ 126..413
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028423"
SQ SEQUENCE 413 AA; 45736 MW; EC51E234CF65D2F3 CRC64;
MASKKFAVKC GNFAVLVDLH VLPQGSNRDS SWFSEQKKEE VCLLLKETID SRVKEYVGIY
KQRKPSSAEF TRSSPLSLKG YGFQITAYFL KRGIHLHCIQ NSQNTELRVF PERFVVCVSQ
LAFGHDIWAN QNEKSTKKAL HGVSDYFPEC AESSPSPGTK LKRNALKEIV RRTKSKGTDV
SKPQPSGDLV GRSSDSVITV VPWRRDASAI LLSESVGQAQ DDIRAAKSHQ ELPVQKLENV
SQTQPGDTRS QQQLHPGEWL KTGLLSRSPA YNYESASPGP KQSLRAAKTQ QKHRNCGSVE
DCDHRRRVSL GNEGLVPEDA DRERSTAVRV LPALELSDPG LLLKQDLAKA KAKEELHALE
NLSSRHLVTN NPGQAQQSDS AAITEQLATD QGGPSKKRKK LQSYNRGCSG KKN
