SLX4_ARTOC
ID SLX4_ARTOC Reviewed; 846 AA.
AC C5FSF3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Structure-specific endonuclease subunit SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN Name=SLX4 {ECO:0000255|HAMAP-Rule:MF_03110}; ORFNames=MCYG_05625;
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480;
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC endonuclease that resolves DNA secondary structures generated during
CC DNA repair and recombination. Has endonuclease activity towards
CC branched DNA substrates, introducing single-strand cuts in duplex DNA
CC close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
CC -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
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DR EMBL; DS995705; EEQ32806.1; -; Genomic_DNA.
DR RefSeq; XP_002845756.1; XM_002845710.1.
DR AlphaFoldDB; C5FSF3; -.
DR SMR; C5FSF3; -.
DR STRING; 554155.C5FSF3; -.
DR PRIDE; C5FSF3; -.
DR EnsemblFungi; EEQ32806; EEQ32806; MCYG_05625.
DR GeneID; 9225003; -.
DR eggNOG; ENOG502S832; Eukaryota.
DR HOGENOM; CLU_016773_0_0_1; -.
DR OMA; TWHEKIL; -.
DR OrthoDB; 231792at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR InterPro; IPR027784; Slx4_ascomycetes.
DR InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR Pfam; PF09494; Slx4; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..846
FT /note="Structure-specific endonuclease subunit SLX4"
FT /id="PRO_0000388032"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 93369 MW; ACFB177AF88261D2 CRC64;
MTDHGPDALD AFSPPRVGSA SPVVISLVSP ALTQMTVTPI DNSPKLPFNL AQGLESDLES
HSDASNPLHP NVSHPMTRVA LGEKAGAENL PVHRTKRRKL GNQRDNTAES MEDLVDCSRN
HFQPAEDEST TQKQKTRKPA KPSEKGQKSE KTANLRLRGK VKKASDTQVL VPIDKSAQDP
SQKFASQHRA DEENGGLHLE EATSRRDYWT PIKDTNSASI DLTGSPVSIQ ADKAQAKSKD
FRELMSEFNF SRETSHEVEA GCQLVNDKPT TKQLLEFMPQ NCRTSKSLDS ESLDTGTSST
SEGNGKRKQT KKAKRSAKSK ITTITSLTTG RYESSLAPEG DHIPSSLVDN MVESIQPAEK
APSNRKNTKP KSKKAIPGRA ECYALLKPAP TMEALKTIEN QALLFGTSSQ LERESSPNVY
GLEPELGRDE VKSNSIQNIS SEPSTGMGVS RFSKSKNLWG ASSRDLDGYL LNVDMIDLVD
PTPKITPKPG DERQSNLSNK NTERNIPEES SLLGEQVNAK DVELPDCLAG EISTSDTMQN
SFEYLNTTNS QDGPVDDSMP NYDQLSTPEL AKKLASFGFR PIKKRERIIE LLEKCWESKR
KSCIEPTTKP AILSTPQVVI QPIPPNANSK FMDSDSAIKP SSVPPKGTRK PKKITSKEIT
NPARSSWSTA KNLKSSSKPT DNMPDSMGSQ SYVQPEIIEI EDSTDENLLE SSKQPRDYRG
AHTLASRSAS SHITPQISSA PSQTVPIQTR ASAGTNEKEI VDLPDIFLQI TNAVKAQPRI
RSVNGVKQPT WHEKIVMYDP IWLDDLTLWL NVEGFKLIKE DREVHPYLVR EWCESKGICC
CFRNKK
