ID   SLX4_ASHGO              Reviewed;         498 AA.
AC   Q750B5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4;
GN   Name=SLX4; OrderedLocusNames=AGR042W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54531.1; -; Genomic_DNA.
DR   RefSeq; NP_986707.1; NM_211769.1.
DR   AlphaFoldDB; Q750B5; -.
DR   SMR; Q750B5; -.
DR   STRING; 33169.AAS54531; -.
DR   EnsemblFungi; AAS54531; AAS54531; AGOS_AGR042W.
DR   GeneID; 4623007; -.
DR   KEGG; ago:AGOS_AGR042W; -.
DR   eggNOG; ENOG502RYEW; Eukaryota.
DR   HOGENOM; CLU_022388_0_0_1; -.
DR   InParanoid; Q750B5; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..498
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388011"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  54691 MW;  AEEB01E2F4C931DC CRC64;
     MDLRRAERNL KILGDANSDE DMPVAHSVEE TQGQALFSES DEADAEEDAA ESPQSGVGGR
     TTTAESGGEE HREQVFLSTQ VQGRIDEFEA TEGARRQFRQ LVTGFTYAQE DGEANAGGRT
     AKRVPKVRRT RRNNTKVRSL TEFNTENFER LRKEDRARSL LTMLSGKTQK VNNLLRGLQQ
     ERSRERAFHG CSVYNEGEWR EIVRLLHERL PKATRSDVAC IKSYVYGDGL DETPWCASHA
     RPPDCPAQSQ ERQGTCGPGD DELRIFTLSQ LLEDQSASED VIPDSMDAGD AVSLGSPQPQ
     AGLSQHSFCP DSTATSPLRP PATPLTRAPA SPLPVRVYTA PASPLDYIPD SEDDPYVLQG
     PSQARSPPSL LEVRRTLKNI GVRPGRSAAA VRKAAAAVAR IEAASDAASL GTASDADRRS
     ALFLRMTALV RRSPRLLAHI YCLRPVALDD LRAVLEADDD FIALLDDSLI RQWADFTGIC
     VKNDTSDSQR PPQPLESQ