ID   SLX4_ASPFC              Reviewed;         811 AA.
AC   B0XUC7;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Structure-specific endonuclease subunit slx4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=slx4; ORFNames=AFUB_020270;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Regulatory subunit of the slx1-slx4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with slx1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
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DR   EMBL; DS499595; EDP53981.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0XUC7; -.
DR   SMR; B0XUC7; -.
DR   PRIDE; B0XUC7; -.
DR   EnsemblFungi; EDP53981; EDP53981; AFUB_020270.
DR   VEuPathDB; FungiDB:AFUB_020270; -.
DR   HOGENOM; CLU_016773_0_0_1; -.
DR   PhylomeDB; B0XUC7; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein.
FT   CHAIN           1..811
FT                   /note="Structure-specific endonuclease subunit slx4"
FT                   /id="PRO_0000388015"
FT   REGION          36..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          579..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..490
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..609
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..641
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   811 AA;  89323 MW;  E62F95015004836F CRC64;
     MCTTTDVVVL SSSPDQIRSC SLANPKCGAE KAFVLSPVSS SPSSLPSSSD LFQPPTRSRF
     FKPGGGNEGS SRTAREESET GTKQNDLAAS RKKAAVRGGR QKRTKEQPPN ESQTLFDNPE
     PPIPKHNGCT SKKGTGSRKK RIDAASKCTK SGSKKITGKV TKPGITETTK FENKTKIVTS
     DVSPGKSPAN KLELEKDGLQ IEVAMKRRLD WTPTKDTGKQ AVALDDTGDN KTRFGELLSE
     YGFLKAAAVS QTDSKLSDGA PTKCRRLELV DTHNPSTSKR TSPDADSDRS NVRSTRSSRA
     PAAEGKSKKR SRKITTLTGR VTALYTKDCT DHLDAANTMI RASEDVSSKL LSKSLDLDSC
     VLAPGDAVDY LQDQDLIFGT CSQLEREDSP TMLRDMQKEI CASKNSMIEN RKPSSTTRAG
     SGLYSHTTVS RFQTQRDLWS VAARDMDGSL AEIEVLDMVD ITDVSELPPK PNGELPDRSE
     KNDEDTVSQG ESSRPIEITD DFGVEVDVRM EYLATSETKP EETAYAASEI RPMPRFADWK
     DSDLSRQVRL YGFKPMKNRR KMIEVLERCW KAQHSSTRTG VQYAPGKPDD GSTGKAGTIG
     SQMNKQSSKM DAAEKMRRES ACLKEKAKSS TALEDKLSHA TDRSSQMLTK SSFAHMEEIE
     DSEDEVIPSP SQLQSLYKRH ISESRSSHPL PVSDTPSTPS SRTRTNADSD TKPSPSDSAT
     ESSLPDLASQ ITKAVRLQPR SFSVDCKRPS WHEKILMYDP IILEDFATWL NIEGLGLVHE
     DREVSAEFVR QWCESNGICC GFRKNSRRSE R