SLX4_ASPFN
ID SLX4_ASPFN Reviewed; 819 AA.
AC B8NLN6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Structure-specific endonuclease subunit slx4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN Name=slx4; ORFNames=AFLA_092520;
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC 167;
RX PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
CC -!- FUNCTION: Regulatory subunit of the slx1-slx4 structure-specific
CC endonuclease that resolves DNA secondary structures generated during
CC DNA repair and recombination. Has endonuclease activity towards
CC branched DNA substrates, introducing single-strand cuts in duplex DNA
CC close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC -!- SUBUNIT: Forms a heterodimer with slx1. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
CC -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
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DR EMBL; EQ963480; EED49171.1; -; Genomic_DNA.
DR RefSeq; XP_002381072.1; XM_002381031.1.
DR AlphaFoldDB; B8NLN6; -.
DR SMR; B8NLN6; -.
DR STRING; 332952.B8NLN6; -.
DR EnsemblFungi; EED49171; EED49171; AFLA_092520.
DR VEuPathDB; FungiDB:AFLA_092520; -.
DR eggNOG; ENOG502S832; Eukaryota.
DR HOGENOM; CLU_016773_0_0_1; -.
DR OMA; TWHEKIL; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR InterPro; IPR027784; Slx4_ascomycetes.
DR InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR Pfam; PF09494; Slx4; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein.
FT CHAIN 1..819
FT /note="Structure-specific endonuclease subunit slx4"
FT /id="PRO_0000388013"
FT REGION 1..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 89189 MW; 851ACB95421BC1A2 CRC64;
MSAAADVIVL SSSPDRIPNG SPVLPAHDPA KLFDLSPPSA SPSPVRSPSE LFQISTRSRF
FELETPSRNK ENKTPKEPPV RKVNTTSKAK SASSQDKPKR RGRKPASESQ TVLGDSGLAG
LAQQSAPKKT AGARKKRVDS EGKRGKATNR TIMGRVAKSG NVQAKPPQEK IMDVSTPNAL
PPTKPASGVV SLEIDGLQLE TAMKRRIDWT PTKDTTARTV ESSQQEVAEA NPQSFGSLLS
EYGFNDISSA QSDVRNLGDD GPTKRRRIEL VDSRLFGSSK PASHDIDDKN LTEDSQQKQP
EPKQKPKKQT KKFTTLTARV TASYLNNSHE GSDSSSKETT TSRENAATSR TRGSKRKGKA
TSKPKEPEFI VLSPEAAAKS LENQELIFGT CSQLEREDSP TSLKELQAAI SESERYAVAE
PSPLSSTLCA TPTSRFTTAR GLWSVAARDL EGSLIRQTEV VDLVDTPEPA KMTTSTNDSR
NEKALEDAAT VPPKEPFDLP QSEPPKLKAI PAAKKEPSPA PGLPTIKASD NLKGTTSQHS
KPQPKMPNYN GFTDAELSRQ VASYGFKPVK NRKAMIDLLQ KCWVSKHGKG TTFETQAGSQ
NTSTEPTPVL TSSEPNTSQK QPRKTATSRK TAAKSKTNPD SNPPPKINSR KTPSSSDATK
APSIQSKPTQ PPPIQSLSNV EEIEDSEEET LPSPFRIQNR YTPQPPETRQ ALPVSKTLYS
PSRPKPRTTK STTNNSATLN QKQPDLADQI FKAMHAQPAG TPSRPSWHEK ILMYDPIILE
DFATWLNTEG LGLVGEDREV SAAFLRKWCE SRGICCCYR
