SLX4_ASPFU
ID SLX4_ASPFU Reviewed; 811 AA.
AC Q4WI38;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Structure-specific endonuclease subunit slx4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN Name=slx4; ORFNames=AFUA_2G03200;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Regulatory subunit of the slx1-slx4 structure-specific
CC endonuclease that resolves DNA secondary structures generated during
CC DNA repair and recombination. Has endonuclease activity towards
CC branched DNA substrates, introducing single-strand cuts in duplex DNA
CC close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC -!- SUBUNIT: Forms a heterodimer with slx1. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
CC -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03110}.
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DR EMBL; AAHF01000008; EAL87417.2; -; Genomic_DNA.
DR RefSeq; XP_749455.2; XM_744362.2.
DR AlphaFoldDB; Q4WI38; -.
DR SMR; Q4WI38; -.
DR STRING; 330879.Q4WI38; -.
DR EnsemblFungi; EAL87417; EAL87417; AFUA_2G03200.
DR GeneID; 3506707; -.
DR KEGG; afm:AFUA_2G03200; -.
DR VEuPathDB; FungiDB:Afu2g03200; -.
DR eggNOG; ENOG502S832; Eukaryota.
DR HOGENOM; CLU_016773_0_0_1; -.
DR InParanoid; Q4WI38; -.
DR OMA; TWHEKIL; -.
DR OrthoDB; 231792at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR InterPro; IPR027784; Slx4_ascomycetes.
DR InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR Pfam; PF09494; Slx4; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..811
FT /note="Structure-specific endonuclease subunit slx4"
FT /id="PRO_0000388014"
FT REGION 38..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 89384 MW; 21AEDC296481B56E CRC64;
MCTTTDVVVL SSSPDQIRSC SLANPKCGAE KAFVLSPVSS SPSFLPSSSD LFQPPTRSRF
FKPGGGNEGS SRTAREESET GTKQNDLAAS RKKAAVRGGR QKRTKEQPPN ESQTLFDNPE
PPIPKHNGCT SKKGTGSRKK RIDAASKCTK SGSKKITGKV TKPGITETTK FENKTKNVTS
DVSPGKSPAN KLELEKDGLQ IEVAMKRRLD WTPTKDTGKQ AVALDDTGDN KTRFGELLSE
YGFLKAAAVS QTDSKLSDGA PTKCRRLELV DTHNPSTSKR TSPDADSDRS NVRSTRSSRA
PAAEGKSKKR SRKITTLTGR VTALYTKDCT DHLDAANTMI RASEDVSSKL LSKSLDLDSC
VLAPGDAVDY LQDQDLIFGT CSQLEREDSP TMLRDMQKEI CASKNSMIEN RKPSSTTRAG
SGLYSHTTVS RFQTQRDLWS VAARDMDGSL AEIEVLDMVD ITDVSELPPK PNGELPDRSE
KNDEDTVSQG ESSRPIEITD DFGVEVDVRM EYLATSETKP EETAYAASEI RPMPRFADWK
DSDLSRQVRL YGFKPMKNRR KMIEVLERCW KAQHSSTRTG VQYAPGKPDD GSTGKAGTIG
SQMNKQSSKM DAAEKMRRES ACLKEKAKSS TALEDKLSHA TDRSSQMLTK SSFAHMEEIE
DSEDEVIPSP SQLQSLYKRH ISESRSSHPL PVSDTPSTPS SRTRTNADSD TKPSPSDSAT
ESSLPDLASQ ITKAVRLQPR SFSVDCKRPS WHEKILMYDP IILEDFATWL NIEGLGLVHE
DREVSAEFVR QWCESNGICC GFRKNSRRSE R
