ID   SLX4_CANAL              Reviewed;         776 AA.
AC   Q5AFV3; A0A1D8PLM6; Q5AF67; Q5AF68;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   OrderedLocusNames=CAALFM_C402590CA; ORFNames=CaO19.10255/10254, CaO19.2740;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017626; AOW29028.1; -; Genomic_DNA.
DR   RefSeq; XP_720490.2; XM_715397.2.
DR   AlphaFoldDB; Q5AFV3; -.
DR   SMR; Q5AFV3; -.
DR   BioGRID; 1221007; 1.
DR   PRIDE; Q5AFV3; -.
DR   GeneID; 3637913; -.
DR   KEGG; cal:CAALFM_C402590CA; -.
DR   CGD; CAL0000175447; SLX4.
DR   VEuPathDB; FungiDB:C4_02590C_A; -.
DR   eggNOG; ENOG502RS18; Eukaryota.
DR   HOGENOM; CLU_429039_0_0_1; -.
DR   InParanoid; Q5AFV3; -.
DR   OrthoDB; 1409030at2759; -.
DR   PRO; PR:Q5AFV3; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..776
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388020"
FT   REGION          201..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   776 AA;  87934 MW;  C9707C7B76F377D7 CRC64;
     MATEYGDDDG GLYFHSTQMQ SIHESLQQEE NQRLYLQTSI KKLESFKHVN NDSSNNSNSG
     AVSVVQIKKK AATKKRKLMA RKPNVKKPKS SSEAVRQAFE KDKFAYFTNN QAKIDDFLPG
     KSTSTEPSTS NQGSLISSDE WNYIKQIYLQ KPTKNKTTLK SIRKRIKQYE NSGTGMWEIA
     ALNVDVSLND EDIQHLYALD EEQMVSDDNS STEDDTDPTQ NDGLILTLSQ NCSTQRDICH
     HEKDDQKYIL IDSSICETYQ QDKSLQRHSQ KDSDNGNTIP DQNSAITIGE MESTAAHEVE
     EIFSTPSYVP SNKLNADQDR SDESESSIIM LADNIVSTQP DIVESISDSE SEIEIIERPR
     LQVLRSVYEN GTSTNQTRQE LTMPKCLENN KISENEEYES EVVESDSTPI ITPVVTPTKK
     PHIFPTNEPA IPIALRSTPN KIKNNVDRIF GSPSPIKLVL ESPLKKHINI EFSDSESIYS
     TAVSQFGTPK QTTSFSPEVL TQKVGSPPLD ACSDSGPTGV VSSMPYKKPH STKRLRTTTL
     EISAALRVKN YTDPKNNITV KKFGEEIKRE FIDLDNEIPD SESSDDDTGF SIIEITRQVE
     ECKEPANDDY SEEQSTDLFQ IGLKNKQETG NTSHMQVPSS PELQFENAGN TFLNSSLVEE
     DEFTKLKATE LRERFKDWGL KPVQRKDKML EILQGISDFI SPESLLALKG FDLQQCVFDK
     LELLIKQDQF WYDRILTFEP IRLEELKQWL NSHNHHLELD ILRLYCDRNC ITTTNT