ID   SLX4_CANDC              Reviewed;         784 AA.
AC   B9WFW5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=SLX4 {ECO:0000255|HAMAP-Rule:MF_03110}; ORFNames=CD36_42550;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
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DR   EMBL; FM992691; CAX42134.1; -; Genomic_DNA.
DR   RefSeq; XP_002419919.1; XM_002419874.1.
DR   AlphaFoldDB; B9WFW5; -.
DR   SMR; B9WFW5; -.
DR   PRIDE; B9WFW5; -.
DR   EnsemblFungi; CAX42134; CAX42134; CD36_42550.
DR   GeneID; 8047666; -.
DR   KEGG; cdu:CD36_42550; -.
DR   CGD; CAL0000168949; Cd36_42550.
DR   eggNOG; ENOG502RS18; Eukaryota.
DR   HOGENOM; CLU_429039_0_0_1; -.
DR   OrthoDB; 1409030at2759; -.
DR   Proteomes; UP000002605; Chromosome 4.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein.
FT   CHAIN           1..784
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388021"
FT   REGION          73..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   784 AA;  88457 MW;  D789F51D3D041A5E CRC64;
     MATETGDDDG GIYFHSTQIQ SIHESLEQEK SQRLYLQASI KKLESFKHVS DESLNNLNPS
     PVSVVQIKKK AATRKRKLSA RKPNLKKPKS SSEVVRQAFE KDKFAYFTNN QARIDEFLTN
     GSVSTENSTS NQGSLISSDE WNYIKQTYLQ QQGESKTTLK GIRNKIKQSK NSGIGMWEIT
     ASNPDISLND EDIQYLHDLD EQQMMSDGNS FTDDDIDPTQ DDGLVLTLSQ NCSSQHDICH
     HEKDHQEHIL INSSIGEAVQ HDRNLESRSQ KYSDNGNTIP DQNSAIRTGE MESTDAHEVQ
     EIFSTPSYVP SNQLNTDKDS SQESGSSIIM LAENIVSTQP DVIESISDSE SEIEIIEKPR
     LQVLQSVYEN DISTNQTRHE SAILKYSENS KQSEHQDYES EVVESDSTPI ITPNVTPKKK
     AHISPVNETH GIMNESPVPL ASRNTPDRIT NIVGRIPSSP SPIKLVLESP LKKQRKIEFS
     DTESIYSTAV SQFGTPKQTT SSPVEVLTSK VGSPQLGICS DSETISVVSS MAHKKSHAAK
     KLRTTTLEVS AALRVKTYTD PENNITVKKL GEEKKREFID LDNEIPDSEN SDDDTGFSII
     EITRQVVERK EHNNDDYSEE QSTDLFQIGL KDKRDIANTS HLQVPSSLVM QLGNTGNTFL
     DSSLVEEDDE IAKLTATELR ERFKDWGLKP VQGKDKMLEI LQGISDFISP ESLLALKGDD
     LQQRVFDKLE LLIKQDQFWY DRILTFEPIR LEEMRQWLNS HNHYLELDML RLYCDRNCIT
     TTNT