ID   SLX4_CANGA              Reviewed;         726 AA.
AC   Q6FJQ6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   OrderedLocusNames=CAGL0M04389g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
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DR   EMBL; CR380959; CAG62514.1; -; Genomic_DNA.
DR   RefSeq; XP_449538.1; XM_449538.1.
DR   PDB; 4XLG; X-ray; 1.78 A; B=647-726.
DR   PDBsum; 4XLG; -.
DR   AlphaFoldDB; Q6FJQ6; -.
DR   SMR; Q6FJQ6; -.
DR   STRING; 5478.XP_449538.1; -.
DR   PRIDE; Q6FJQ6; -.
DR   EnsemblFungi; CAG62514; CAG62514; CAGL0M04389g.
DR   GeneID; 2891547; -.
DR   KEGG; cgr:CAGL0M04389g; -.
DR   CGD; CAL0137205; CAGL0M04389g.
DR   VEuPathDB; FungiDB:CAGL0M04389g; -.
DR   eggNOG; ENOG502RYEW; Eukaryota.
DR   HOGENOM; CLU_022388_0_0_1; -.
DR   InParanoid; Q6FJQ6; -.
DR   OMA; FMNTQIQ; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA damage; DNA recombination; DNA repair; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..726
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388022"
FT   REGION          156..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           657..669
FT                   /evidence="ECO:0007829|PDB:4XLG"
FT   HELIX           672..679
FT                   /evidence="ECO:0007829|PDB:4XLG"
FT   HELIX           686..696
FT                   /evidence="ECO:0007829|PDB:4XLG"
FT   HELIX           698..702
FT                   /evidence="ECO:0007829|PDB:4XLG"
FT   HELIX           705..715
FT                   /evidence="ECO:0007829|PDB:4XLG"
SQ   SEQUENCE   726 AA;  82272 MW;  6687314DC405E245 CRC64;
     MDFERAQKNF DAFVINGETD ETPNDELRHE SQHSDFDTCG TQVPEMNFSD DDNSDCGNNE
     IDRLAHNATE TTDKEGDDSI IVTQERIAEN RNNSVIEIED EDQIDLSVVN SKEEDNIFLN
     TQIQSRLDDH EKDLQQKAVL KSFNFEYVDK DESPNMMGSR YIRKKSPKKR NSRKNTEEAI
     QASKSISKRQ NNANSLLQIL SGKKSKVNAI IKNQRFKYES KTGVLKRASQ VSNSTSTTYG
     KEEWKQIKNV LRTRYSKLEN SDDRELENFI NYLSEQLEKE PNLWTSSQIA ISTNENNESY
     RQDSIGSLLT LSQVMGDKSA ILESDDEYPD VRPNGESFFK CADDSQQLKD DLNIVSQTNS
     NTNVSGVESV HGLEGKNLYS MGEKEEVTNK MTDFVSKEVE QSQVPLLSIH RRGRNNGSYF
     IFDSSDEYKT IIEIDSSIRQ PMDNSNEPSI TNHRRTPVFS KSQSILDQEC DSIEDISLSQ
     GSFKAVTTLI SPVKDGSTAQ NSQAMDIPTQ FSGIPRLLDL KTVPKLPFES FNENSKDYRI
     IISKKKLLEL KQAIKRLANI ELTEEHEVLG NIDGQPGEEL FAVVLSISNN LELLSSPGVD
     THTKEKSPSL AELRKDLDKI GLKPVRLKSQ IIENLASASQ VVTVDESNQK KVGVTSKSEV
     FEFLTHLVKQ EPDLLTRIYC FQPITMNDLI NKLRNKDSFV DLIDDGTIRE WTDKLGICIR
     SNNLKD