ID   SLX4_DEBHA              Reviewed;         788 AA.
AC   Q6BP70;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=SLX4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   OrderedLocusNames=DEHA2E16038g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
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DR   EMBL; CR382137; CAG88253.2; -; Genomic_DNA.
DR   RefSeq; XP_460000.2; XM_460000.1.
DR   AlphaFoldDB; Q6BP70; -.
DR   SMR; Q6BP70; -.
DR   EnsemblFungi; CAG88253; CAG88253; DEHA2E16038g.
DR   GeneID; 2902265; -.
DR   KEGG; dha:DEHA2E16038g; -.
DR   VEuPathDB; FungiDB:DEHA2E16038g; -.
DR   eggNOG; ENOG502RS18; Eukaryota.
DR   HOGENOM; CLU_429039_0_0_1; -.
DR   InParanoid; Q6BP70; -.
DR   OMA; CKEPAND; -.
DR   OrthoDB; 1409030at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..788
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388027"
FT   REGION          59..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  90082 MW;  EF9607E00359DB82 CRC64;
     MSRLTEDSIG DINLASTQMQ GRLEEFDEIS KEEENMKKRI ERLRKFKNID TNTNHTIGLQ
     NENLENKNKD TSITKPKRRS KRDNNRIKSL TSLMEETYNK GKSFQELKQS KLGQKDAQLS
     IFQYFSGHKE KIGDILKRIE SIEKRKLESS DVPEIEHESR ILYTKKEWTD IIKRIRLRFP
     ELSSRTKKSL KYITNKIQIQ NQSQLISEYP KNNSSIWSQA SAPPDTEFTD DDLKWLYDLT
     SEQIINESTI LQNDLEESDN ETPFVMTLSQ VMNTTKSEDT IDREFDVISD SSPEPSPIRV
     SFCCRDEQSD KALHLSEQKI QVKNSIYDPE FNGNEIFSHQ KDSVETAVSI ESFPFVQSGQ
     RESITGDIAE ISEDNFQVSE TAPRQPQAIH GTQEAPIEIS SSSINRGKTN LMSEEDRASH
     NEAEEVIISS PIKDSELFKT PTKRTPGSKN IMSSPFRLHC NSSPLSIRSN SVTPRHERIV
     SEESSAYSTA RSKFKLSSAQ PIPSQYQFDD SEEEAIFSSM PARQAYKKRK VYHTSRLLID
     GGLYVELMNE NSKVKIKTIE TKRQPVDSEN EIRDSEDEGE HDNSLSVIEI TREVDDTDDL
     VNLGRNPRNE NDTSVLQVPS SPQIDNSNVL GSLYTSQAAD SAFGSEKILE DPIRSNALEL
     TQDEFNNMST KDLKAKFQEW GLKPVKGKEK MIQILSETNK LVSQSQLNDS QDKPMTASQH
     TIKTNIYNRI SFHLKQDQYW LDKILSFEPI NLCMLQEWLA SGSAGVKLET DILEKYCDEL
     GITYTDIK