ID   SLX4_KOMPG              Reviewed;         652 AA.
AC   C4R5N0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4;
GN   Name=SLX4; OrderedLocusNames=PAS_chr3_0813;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN392321; CAY70866.1; -; Genomic_DNA.
DR   RefSeq; XP_002493045.1; XM_002493000.1.
DR   AlphaFoldDB; C4R5N0; -.
DR   EnsemblFungi; CAY70866; CAY70866; PAS_chr3_0813.
DR   GeneID; 8200307; -.
DR   KEGG; ppa:PAS_chr3_0813; -.
DR   HOGENOM; CLU_429039_0_0_1; -.
DR   InParanoid; C4R5N0; -.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..652
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388042"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          37..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  74766 MW;  710A77AEDCE33160 CRC64;
     MEFVSTQIQS AYEDYEEKER HDRDIKKKLA SFKSAEFGHN FAEQTSQNSN PRKRKISEKS
     QKERPIRSLN AQVLNMFHGN VELIKQQRAL LKVLSGKKRK VNEVLKHVEN IELENSTTHR
     DKRKIAGTRI NSSTFPDDFG EVLYTKNEWD LLINSIRIRF PRLSATSRKT LNMITEKYNE
     RLHSAEVSIW DASSMPPIQL TSDDIRVLHD LKEDDETEPN ELESISDTRS VILTLSQALK
     QDTSKIVEEE QNIEEVEGGM PLSQGVEDVP DSEPEVLAKN ERSIISLNSD MIVQSSQVEP
     IILSSDAGTP QRRRDSSQLT QPLEEPILTT HLKSSPALSK HSKTPTSTQS PIKLPFNFRE
     STPAIDQLPS FLDDWRGAVV SDESQEVVYS TAQNHSQTKS SAYSTARSNF EDNSTRKTLN
     TGENEDSITV LKKTIVPFYG KINPEKEIVY HSIEENEEGE TREIKSKLMD RMRLPNNEEI
     NVIPDSESDS EHDVSFLEVI SVVKRREPEL EGDFSGFNTN LFNPPRQDTL ISLDENDSEE
     VFRSQSQNYI QLNNTQDQTQ DPTSKQREPT NTQLEPDNEV VNDEETFEKW KLLLKSNPEI
     YQQIVTFKPL FLSEIIKFLE ANGFLMPKPK DVNLLKRFLD TQSVCFTERA RK