ID   SLX4_TALSN              Reviewed;         800 AA.
AC   B8MED8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Structure-specific endonuclease subunit slx4 {ECO:0000255|HAMAP-Rule:MF_03110};
GN   Name=slx4; ORFNames=TSTA_016430;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Regulatory subunit of the slx1-slx4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA. {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- SUBUNIT: Forms a heterodimer with slx1. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03110}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03110}.
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DR   EMBL; EQ962656; EED16565.1; -; Genomic_DNA.
DR   RefSeq; XP_002483799.1; XM_002483754.1.
DR   AlphaFoldDB; B8MED8; -.
DR   SMR; B8MED8; -.
DR   STRING; 441959.B8MED8; -.
DR   PRIDE; B8MED8; -.
DR   EnsemblFungi; EED16565; EED16565; TSTA_016430.
DR   GeneID; 8106416; -.
DR   VEuPathDB; FungiDB:TSTA_016430; -.
DR   eggNOG; ENOG502S832; Eukaryota.
DR   HOGENOM; CLU_016773_0_0_1; -.
DR   InParanoid; B8MED8; -.
DR   OMA; TWHEKIL; -.
DR   OrthoDB; 231792at2759; -.
DR   PhylomeDB; B8MED8; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   HAMAP; MF_03110; Endonuc_su_Slx4; 1.
DR   InterPro; IPR027784; Slx4_ascomycetes.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..800
FT                   /note="Structure-specific endonuclease subunit slx4"
FT                   /id="PRO_0000388048"
FT   REGION          16..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          590..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..639
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   800 AA;  87385 MW;  43C19E358642A232 CRC64;
     MTSRLDHTIV IPSSPEQNWA RSVSPCTPTR LFGLPPMSIS PPSLPSPSRL FEEIGLGQQK
     NPPSPKSPFS SAAGKTATSK AITENPSRNE SSSKRGRPGS SEAKTAGSRK NSKSQETRNK
     ILTGRVAKPT TVSKAKATAA SKSKDTSVVK AKAGTKKSKP ASQNKKDKLA EEAEAEAKEV
     ADAEGLNLEE ALKRRSDWTP PKALSLVSID EDTPSQGSGT KLSFGDVLRD YHYNRENSSC
     EPAQPSKEGN PTKRRRLELV EFEVLQERKP IQQKQIKDAV KTRKTKSKPK KQLNTITARV
     TARYEQIGEL EDLFVYNEES SCETSECLKK PTKPKKETAG KQKEPEYIIL SPDAATKSLN
     DQNFLFGTCS QLERDDSPTF FEETQTAIQL SECLTFKKTA STITTASSAM SIATRFTGKK
     SHWSEAARDF NGAVVQPEII DMTDSPTVSV ALSRLSEVKH DAPKMASLVS SQSVSATNSL
     VPKDVVTASK PAADVQLASS GPEPNKTELA AGPFRKTASR LPEMPNFNGY TDSELKNQVL
     SYGFSLRAVR GRKKMIELLD KCWQSKHGNT ATAAIVETSS SAAINETVSV SAARHSDTQV
     SDKLPTRKKK TTPSRLEPKT TSRAGKKKVS EKPLAGKADK PVEKAASPIP ASTYNMVDEI
     EDSEEEIIPS PTRIQIQRQS SSRQTTPAIS CLPLGTKSKR SLKSTKSSTY DEATLLELQS
     SITKAIHLQT RPRRSLGGSS YSPQLTWHEK ILLYEPIILE DFAAWLNTEG FALACEDREV
     GVALVRTWCE SRGICCTFRP