ID   SLX4_ZYGRC              Reviewed;         549 AA.
AC   C5DY61;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Structure-specific endonuclease subunit SLX4;
GN   Name=SLX4; OrderedLocusNames=ZYRO0F10516g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Regulatory subunit of the SLX1-SLX4 structure-specific
CC       endonuclease that resolves DNA secondary structures generated during
CC       DNA repair and recombination. Has endonuclease activity towards
CC       branched DNA substrates, introducing single-strand cuts in duplex DNA
CC       close to junctions with ss-DNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with SLX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated in response to DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLX4 family. {ECO:0000305}.
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DR   EMBL; CU928178; CAR28722.1; -; Genomic_DNA.
DR   RefSeq; XP_002497655.1; XM_002497610.1.
DR   AlphaFoldDB; C5DY61; -.
DR   SMR; C5DY61; -.
DR   STRING; 559307.C5DY61; -.
DR   EnsemblFungi; CAR28722; CAR28722; ZYRO0F10516g.
DR   GeneID; 8205420; -.
DR   KEGG; zro:ZYRO0F10516g; -.
DR   HOGENOM; CLU_022388_0_0_1; -.
DR   InParanoid; C5DY61; -.
DR   Proteomes; UP000008536; Chromosome F.
DR   GO; GO:0033557; C:Slx1-Slx4 complex; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   InterPro; IPR018574; Structure-sp_endonuc_su_Slx4.
DR   Pfam; PF09494; Slx4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..549
FT                   /note="Structure-specific endonuclease subunit SLX4"
FT                   /id="PRO_0000388051"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..293
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  61482 MW;  E38D1AD541EA8062 CRC64;
     MDFHRANRNL QLVESGVSDG RNPESFSLDE TQVPVSSGFS SDSDKDQQEQ IFINTQVQGR
     LDEAEEADKV RANLGQFRYD SQDSAISPKH KSAIQRPSAR TTKRSSSSQR RKAPTKAQSL
     LKQLSGKHAK VQDMIKYQQK LDSLAGSQQR AKSKGKTTKT KKQQEKRYDT YNANEWQHIY
     NLLLEKFPHT RPSEVEDVYQ YLYGDESEDQ PLWNESQRPI EPESQDLGFL PPPPADKQRV
     SVLSLSQVMD DKHSREPDED IIVPDSTDEE YIVIPIPSSP QPLRPPLATK PPLLTKPPLK
     KVESDAGTPK TAHSPSDGVI DLTNGSFKVV KSLISPLKEE TAQVQVPATR MPTLGTTPNL
     APTKEQPLRY RLHRSQLESF SAVEGLIVCS PGPSQDDVPV PDTESEDSAA EDHCMVELQP
     SILASRTPSP SVQSDWNSQS AQQLRQSMKS LGLKTSRSKR QMLHSLQQAS QVLEIDTGGQ
     ENQRQEIHDY LTSLVQSSPV LLEKVYTFQP IASKELLTKL TEANPFVDVI DEYTIREWAD
     YQGICLTTS