BICRA_MOUSE
ID BICRA_MOUSE Reviewed; 1578 AA.
AC F8VPZ9;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=BRD4-interacting chromatin-remodeling complex-associated protein {ECO:0000305};
DE AltName: Full=Glioma tumor suppressor candidate region gene 1 protein {ECO:0000305};
GN Name=Bicra {ECO:0000312|MGI:MGI:2154263};
GN Synonyms=Gltscr1 {ECO:0000312|MGI:MGI:2154263};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007744|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000312|Ensembl:ENSMUSP00000092416}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J;
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [4] {ECO:0007744|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [5] {ECO:0000312|Ensembl:ENSMUSP00000148012}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J;
RG Ensembl;
RL Submitted (JUL-2016) to UniProtKB.
RN [6]
RP IDENTIFICATION IN THE GBAF COMPLEX.
RX PubMed=29374058; DOI=10.1074/jbc.ra117.001065;
RA Alpsoy A., Dykhuizen E.C.;
RT "Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog
RT GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.";
RL J. Biol. Chem. 293:3892-3903(2018).
CC -!- FUNCTION: Component of SWI/SNF chromatin remodeling subcomplex GBAF
CC that carries out key enzymatic activities, changing chromatin structure
CC by altering DNA-histone contacts within a nucleosome in an ATP-
CC dependent manner (PubMed:29374058). May play a role in BRD4-mediated
CC gene transcription (By similarity). {ECO:0000250|UniProtKB:Q9NZM4,
CC ECO:0000269|PubMed:29374058}.
CC -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The
CC canonical complex contains a catalytic subunit (either
CC SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1,
CC ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47.
CC Other subunits specific to each of the complexes may also be present
CC permitting several possible combinations developmentally and tissue
CC specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at
CC least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF
CC subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53,
CC SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with
CC BRD4; the interaction bridges BRD4 to the GBAF complex (By similarity).
CC {ECO:0000250|UniProtKB:Q9NZM4, ECO:0000269|PubMed:29374058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NZM4}.
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DR EMBL; AC148990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC151733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS39780.1; -.
DR RefSeq; NP_001074887.1; NM_001081418.1.
DR RefSeq; XP_006539980.1; XM_006539917.3.
DR AlphaFoldDB; F8VPZ9; -.
DR ComplexPortal; CPX-4202; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant.
DR ComplexPortal; CPX-4221; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant.
DR ComplexPortal; CPX-4227; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant.
DR ComplexPortal; CPX-4229; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant.
DR STRING; 10090.ENSMUSP00000092416; -.
DR iPTMnet; F8VPZ9; -.
DR PhosphoSitePlus; F8VPZ9; -.
DR EPD; F8VPZ9; -.
DR jPOST; F8VPZ9; -.
DR MaxQB; F8VPZ9; -.
DR PaxDb; F8VPZ9; -.
DR PeptideAtlas; F8VPZ9; -.
DR PRIDE; F8VPZ9; -.
DR ProteomicsDB; 333221; -.
DR Antibodypedia; 65070; 78 antibodies from 18 providers.
DR DNASU; 243842; -.
DR Ensembl; ENSMUST00000094821; ENSMUSP00000092416; ENSMUSG00000070808.
DR Ensembl; ENSMUST00000210781; ENSMUSP00000148012; ENSMUSG00000070808.
DR GeneID; 243842; -.
DR KEGG; mmu:243842; -.
DR UCSC; uc009fgu.1; mouse.
DR CTD; 29998; -.
DR MGI; MGI:2154263; Bicra.
DR VEuPathDB; HostDB:ENSMUSG00000070808; -.
DR eggNOG; ENOG502QU2K; Eukaryota.
DR GeneTree; ENSGT00940000159112; -.
DR HOGENOM; CLU_002283_0_0_1; -.
DR InParanoid; F8VPZ9; -.
DR OMA; WVGQSHS; -.
DR OrthoDB; 352636at2759; -.
DR PhylomeDB; F8VPZ9; -.
DR TreeFam; TF335495; -.
DR BioGRID-ORCS; 243842; 9 hits in 71 CRISPR screens.
DR ChiTaRS; Bicra; mouse.
DR PRO; PR:F8VPZ9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; F8VPZ9; protein.
DR Bgee; ENSMUSG00000070808; Expressed in embryonic brain and 214 other tissues.
DR Genevisible; F8VPZ9; MM.
DR GO; GO:0000785; C:chromatin; IC:ComplexPortal.
DR GO; GO:0140288; C:GBAF complex; IC:ComplexPortal.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
DR GO; GO:0140537; F:transcription regulator activator activity; ISO:MGI.
DR GO; GO:0006338; P:chromatin remodeling; IC:ComplexPortal.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IC:ComplexPortal.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IC:ComplexPortal.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IC:ComplexPortal.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IC:ComplexPortal.
DR InterPro; IPR038842; BICRA.
DR InterPro; IPR015671; GSCR1_dom.
DR PANTHER; PTHR15572:SF1; PTHR15572:SF1; 1.
DR Pfam; PF15249; GLTSCR1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..1578
FT /note="BRD4-interacting chromatin-remodeling complex-
FT associated protein"
FT /id="PRO_0000445345"
FT REGION 80..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1342..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..841
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..891
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..951
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1372
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1560
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 929
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZM4"
FT MOD_RES 931
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZM4"
FT MOD_RES 1067
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZM4"
FT MOD_RES 1427
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZM4"
FT CROSSLNK 1327
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NZM4"
SQ SEQUENCE 1578 AA; 161354 MW; A9188E16879ADED1 CRC64;
MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDAPVE AQSAFYEGPG LHVQEAAANH
LNPEPSQPAP SVDLDFLEDD ILGSPAAGGG GGGGGAPDQP CDILQQSLQE ANITEQTLEA
EAELDLGPFQ LPTLQPADNG AGATGAAGAT AVTAGPQALF PGSADLLGLQ APPTVLTHQA
LVPPQDVVNK ALSVQPFLQP VGLGNVTLQP ISGLQGLPNG SPGNAAAATL GLTPIQVVGQ
PVMALNPPTS QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLPAAVTTT
LNGNSVFAGT GAATAAASGA PSGQPLAVAP GLGTSPLVQA PSVILHRTPT PIQPKPTGVL
PSKLYQLTPK PFPPTGATLT IQGEPGTLPQ QPKAPQNLTF MATGKAGQNV VLSGFPAPAL
QANVFKQPPV TTTGTAPPQP PGALSKPMSV HLLNQGSSIV IPAQHMLPGQ NQFLLPGTPA
VQLPQSLSAL PANVGGQILT AAAPHAGGQL IANPILTNQN LAGPLSLGPV LAPHSGAHSA
AHILSAAPIQ VGQPALFQMP VSLATGSLPT QSQPAPTGPT ATTVLQGVTL PPSAVAMLNT
PDGLVQPSTP AATTGEATPV LAVQPATQVP PAVTTPLPMG LQQPQAQQPP QVPTPQAATQ
PQATPPQASP SLASSPEKIV LGQAPPAATT AILTQDSLQM FLPQERSQQP LSTEGPHLSV
PASVIVSAPP PAQDPALATP VTKGAGLGAQ TPDSRASPAP APQIPAAAPL KAPGPASSPS
LPHQAPLGDS PHMPSPHPAR PPSRPPSRPH SRPPSQPQSL TCPPSEPTLH PCPPPQGPPT
LPGIFVIQNQ LGAPPPASTP ASTAPGPPQP PLRPPSQPPE GPLPPASHLP PASTPSAVAS
SSEPSARLPV PTPPDFQLQF PPSQGPHKSP TPPPALHMVP EPTAPPPPPP RTFQMVTAPF
PALPQPKALL ERFHQVPSGI ILQNKAGGTP TTPQTSTTLG TLTGPTASVL VSGQAPPGTP
AASSHVPAST PMATTGLPPL LPAENKAFAS NLPTLSVAKA TVSGPGKPPA IQYDSKLCSL
KKQPLLQPSK EACFLEHLHK HQGSVLHPDY KTAFPSFEDA LHRLLPYHVY QGALPSPNDY
HKVDEEFETV STQLLKRTQA MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD
KQLAKEKPDE YVSSSRSLGF PVPVSSEGHR LPSHGQSSSS STSGTSAQPP PHLPTKLVIR
HGGAGGSPSV TWARASSSLS STSSSSSSSS AASSLDADED GPMPTRNRPP IKTYEARSRI
GLKLKIKQEA GLSKVVHNTA LDPVHQPLPA PTPAKGAEPP PHPAPPPLPP ATQAQMNGTL
DHPPPAVRKP TVPASCPRLP LRKTYRENMG NPGAAEGAQG RPRGAGSPTP LPTKVDEATS
GLIRELAAVE DELYQRVLKG GPPPPETPAS ATSQGPTEPS WEAPVLPPAK RRKSESPDVD
QASFSSDSPQ DDTLTEHLQS AIDSILNLQQ APGRTPAGPY PHTGPTPGTP TSPAPLHRPD
AFPPSSHNGG LGARTLNR
