ID   SLX9_MOUSE              Reviewed;         219 AA.
AC   P58468;
DT   13-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Ribosome biogenesis protein SLX9 homolog {ECO:0000305};
GN   Name=Slx9; Synonyms=Fam207a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA   Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA   Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT   "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT   chromosome 21 transcription map.";
RL   Genomics 78:46-54(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May be involved in ribosome biogenesis.
CC       {ECO:0000250|UniProtKB:P53251}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P53251}.
CC   -!- SIMILARITY: Belongs to the SLX9 family. {ECO:0000305}.
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DR   EMBL; AF391115; AAL34506.1; -; mRNA.
DR   EMBL; BC034216; AAH34216.1; -; mRNA.
DR   CCDS; CCDS23955.1; -.
DR   RefSeq; NP_598759.1; NM_133998.3.
DR   AlphaFoldDB; P58468; -.
DR   BioGRID; 224384; 1.
DR   STRING; 10090.ENSMUSP00000036382; -.
DR   iPTMnet; P58468; -.
DR   PhosphoSitePlus; P58468; -.
DR   EPD; P58468; -.
DR   jPOST; P58468; -.
DR   MaxQB; P58468; -.
DR   PaxDb; P58468; -.
DR   PeptideAtlas; P58468; -.
DR   PRIDE; P58468; -.
DR   ProteomicsDB; 277019; -.
DR   Antibodypedia; 49420; 101 antibodies from 15 providers.
DR   DNASU; 108707; -.
DR   Ensembl; ENSMUST00000045454; ENSMUSP00000036382; ENSMUSG00000032977.
DR   GeneID; 108707; -.
DR   KEGG; mmu:108707; -.
DR   UCSC; uc007fvt.2; mouse.
DR   CTD; 108707; -.
DR   MGI; MGI:1916334; Fam207a.
DR   VEuPathDB; HostDB:ENSMUSG00000032977; -.
DR   eggNOG; ENOG502S25R; Eukaryota.
DR   GeneTree; ENSGT00390000015709; -.
DR   HOGENOM; CLU_099072_0_0_1; -.
DR   InParanoid; P58468; -.
DR   OMA; KIKHVRQ; -.
DR   OrthoDB; 1611351at2759; -.
DR   PhylomeDB; P58468; -.
DR   TreeFam; TF336348; -.
DR   BioGRID-ORCS; 108707; 7 hits in 73 CRISPR screens.
DR   ChiTaRS; Fam207a; mouse.
DR   PRO; PR:P58468; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; P58468; protein.
DR   Bgee; ENSMUSG00000032977; Expressed in urinary bladder urothelium and 261 other tissues.
DR   ExpressionAtlas; P58468; baseline and differential.
DR   Genevisible; P58468; MM.
DR   GO; GO:0030686; C:90S preribosome; IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:InterPro.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   InterPro; IPR028160; Slx9-like.
DR   Pfam; PF15341; SLX9; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..219
FT                   /note="Ribosome biogenesis protein SLX9 homolog"
FT                   /id="PRO_0000079529"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         38
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19144319,
FT                   ECO:0007744|PubMed:21183079"
FT   MOD_RES         192
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NSI2"
SQ   SEQUENCE   219 AA;  24814 MW;  A51E445BB53986C1 CRC64;
     MGKVRALRAR VHRAAVRPDG DSAPGPVPRA VEPALPQSPA GGAGAKDWTF VHNDIFARTQ
     IDPSALVQRL ELDQRSVVSL KRGAEPKAIL PKKEKLKLRR ERWLQKIEAI KLAEQKLREE
     RKRKAMVVVG DLHPLRDALP ELQELEAGRQ RQQARRRVTS KPRPVELSRM TTVQRQQLLE
     EERTRFQKLL ASPTYRASPL LAIGQQLAHQ MQLEGGKQL