BICRD_DROME
ID BICRD_DROME Reviewed; 620 AA.
AC Q8SWR2; Q9VUA2; Q9VUA3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Bicaudal D-related protein homolog;
DE Short=BICD-related protein homolog;
GN ORFNames=CG17365, CG32137;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the BICDR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF49786.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE014296; AAF49786.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014296; AAF49787.2; -; Genomic_DNA.
DR EMBL; AY095527; AAM12258.1; -; mRNA.
DR RefSeq; NP_729935.1; NM_168563.2.
DR RefSeq; NP_729936.1; NM_168564.2.
DR AlphaFoldDB; Q8SWR2; -.
DR SMR; Q8SWR2; -.
DR BioGRID; 64878; 3.
DR IntAct; Q8SWR2; 5.
DR STRING; 7227.FBpp0075500; -.
DR PaxDb; Q8SWR2; -.
DR DNASU; 39537; -.
DR EnsemblMetazoa; FBtr0075758; FBpp0075500; FBgn0052137.
DR GeneID; 39537; -.
DR KEGG; dme:Dmel_CG32137; -.
DR UCSC; CG32137-RA; d. melanogaster.
DR FlyBase; FBgn0052137; CG32137.
DR VEuPathDB; VectorBase:FBgn0052137; -.
DR eggNOG; ENOG502QUA9; Eukaryota.
DR GeneTree; ENSGT00940000171206; -.
DR InParanoid; Q8SWR2; -.
DR OMA; IDMHELI; -.
DR OrthoDB; 595515at2759; -.
DR PhylomeDB; Q8SWR2; -.
DR BioGRID-ORCS; 39537; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG32137; fly.
DR GenomeRNAi; 39537; -.
DR PRO; PR:Q8SWR2; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0052137; Expressed in mouthpart and 36 other tissues.
DR ExpressionAtlas; Q8SWR2; baseline and differential.
DR Genevisible; Q8SWR2; DM.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..620
FT /note="Bicaudal D-related protein homolog"
FT /id="PRO_0000302865"
FT REGION 23..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..332
FT /evidence="ECO:0000255"
FT COILED 449..578
FT /evidence="ECO:0000255"
FT COMPBIAS 23..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 70236 MW; F945A1AB99506BF9 CRC64;
MHKPKLANAI TAAAIASSIS TKNNNNNSIV GGSSSSSSGG NKSKRPRQFG QYSIGVGTGA
GAGGLLRSDD SGFDHLDYSS LIGDSIDLEH YISAMEARRH DQEPDVWAQL QQKESDILLA
AELGKALLEK NEELVKQQEK LIEDYSSKIE KLEQEKHVLR QKLAIAEDES DQRVLELQSD
LTELKDKLQT QDTAIRQAEK EKTILIDELQ HQNTRLTEQI QEAHATELKL SAQIQELKDQ
YHYRNSSLQE HVNSLESIKT ELNLTTGKRQ ELERRLQIAQ EEKESLTSSL EESSDRIHML
ERHAREQETK LETTLQALER SQRENNVLSE RLGADTNSST PGRKSLQFEM ECDEDDGSYT
ETGKPNQMFV EARSVYIQLK SLVDSLKVSH DDDSGLNSDI SLELESMDNT ISSSERHEDG
HLAIEFRQGM LSSMSDELTR LLLNLDAGNF KKMLDQTRNL VLEQEDEIKR SHQLIQQLEA
KVTVTDVELQ NVKEERDQAR GDLEDNTDRD ELLSKAQTER DAANDRRTKA EVELAKTRVE
LMQANSQLLE SIQQKVELSQ QLEQWQMDMH ELIDEQMRSK LINNRRAMAA ESSAPSPPSS
AAANLAKRVT SYKLWSLFQR
