SLY1_DROME
ID SLY1_DROME Reviewed; 639 AA.
AC Q24179; B7YZZ1; B7YZZ2; O02560; Q4V684; Q7KU13; Q8SZB1; Q9VQC9;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 4.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Protein sly1 homolog;
GN Name=Slh; ORFNames=CG3539;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R {ECO:0000269|PubMed:8675012};
RX PubMed=8675012; DOI=10.1101/gad.10.10.1260;
RA Merli C., Bergstrom D.E., Cygan J.A., Blackman R.K.;
RT "Promoter specificity mediates the independent regulation of neighboring
RT genes.";
RL Genes Dev. 10:1260-1270(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL48617.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-182.
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Non-vital for development. {ECO:0000269|PubMed:8675012}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In embryos, from stage 14, expression is seen in
CC posterior midgut, esophagus and salivary glands. No expression is seen
CC in larval imaginal disks. {ECO:0000269|PubMed:8675012}.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC47550.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAY54838.1; Type=Miscellaneous discrepancy; Note=Differs from position 182 onward for unknown reasons.; Evidence={ECO:0000305};
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DR EMBL; U63852; AAC47550.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014134; AAF51247.3; -; Genomic_DNA.
DR EMBL; AE014134; ACL82976.2; -; Genomic_DNA.
DR EMBL; AY070995; AAL48617.1; -; mRNA.
DR EMBL; BT022422; AAY54838.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001137769.2; NM_001144297.2.
DR RefSeq; NP_995614.1; NM_205892.2.
DR AlphaFoldDB; Q24179; -.
DR SMR; Q24179; -.
DR BioGRID; 59661; 29.
DR IntAct; Q24179; 3.
DR STRING; 7227.FBpp0089084; -.
DR PaxDb; Q24179; -.
DR PRIDE; Q24179; -.
DR DNASU; 33434; -.
DR EnsemblMetazoa; FBtr0077782; FBpp0077461; FBgn0264978.
DR EnsemblMetazoa; FBtr0335169; FBpp0307162; FBgn0264978.
DR GeneID; 33434; -.
DR KEGG; dme:Dmel_CG3539; -.
DR CTD; 33434; -.
DR FlyBase; FBgn0264978; Slh.
DR VEuPathDB; VectorBase:FBgn0264978; -.
DR eggNOG; KOG1301; Eukaryota.
DR GeneTree; ENSGT00550000074845; -.
DR HOGENOM; CLU_016216_3_1_1; -.
DR InParanoid; Q24179; -.
DR OMA; DRQLDNF; -.
DR OrthoDB; 917326at2759; -.
DR PhylomeDB; Q24179; -.
DR Reactome; R-DME-204005; COPII-mediated vesicle transport.
DR Reactome; R-DME-8980692; RHOA GTPase cycle.
DR BioGRID-ORCS; 33434; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33434; -.
DR PRO; PR:Q24179; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0264978; Expressed in embryonic/larval hemocyte (Drosophila) and 45 other tissues.
DR Genevisible; Q24179; DM.
DR GO; GO:0005801; C:cis-Golgi network; ISS:ParkinsonsUK-UCL.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0005798; C:Golgi-associated vesicle; ISS:ParkinsonsUK-UCL.
DR GO; GO:0005886; C:plasma membrane; ISS:ParkinsonsUK-UCL.
DR GO; GO:0044877; F:protein-containing complex binding; ISS:ParkinsonsUK-UCL.
DR GO; GO:0000149; F:SNARE binding; ISS:FlyBase.
DR GO; GO:0019905; F:syntaxin binding; ISS:ParkinsonsUK-UCL.
DR GO; GO:0000902; P:cell morphogenesis; IMP:FlyBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; ISS:ParkinsonsUK-UCL.
DR GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:ParkinsonsUK-UCL.
DR GO; GO:0001666; P:response to hypoxia; ISS:ParkinsonsUK-UCL.
DR GO; GO:0009636; P:response to toxic substance; ISS:ParkinsonsUK-UCL.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:ParkinsonsUK-UCL.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR Gene3D; 3.90.830.10; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Reference proteome; Repeat.
FT CHAIN 1..639
FT /note="Protein sly1 homolog"
FT /id="PRO_0000206300"
FT REPEAT 85..121
FT /note="1"
FT /evidence="ECO:0000305"
FT REPEAT 203..245
FT /note="2"
FT /evidence="ECO:0000305"
FT REPEAT 423..460
FT /note="3"
FT /evidence="ECO:0000305"
FT REPEAT 464..500
FT /note="4"
FT /evidence="ECO:0000305"
FT REGION 85..500
FT /note="4 X approximate repeats"
SQ SEQUENCE 639 AA; 72366 MW; 3D99ACBBA028A739 CRC64;
MLTLRERQIN AIKQMLNLNS QQPKALAAEP VWKILIYDRV GQDIISPIIS IKELRELGVT
LHVQLHSDRD SIPDVPAIYF CLPTDENLDR IQQDFSSGLY DVYHLNFLAP ITRSKIENLA
AAALHAGCVA NIHRVYDQYV NFISLEDDFF ILKHQQSDQL SYYAINRANT RDEEMEALMD
SIVDSLFALF VTLGNVPIIR CPRNSAAEMV ARKLEKKLRE NLWDARANLF HMDATQAGGG
VFSFQRPVLL LLDRNMDLAT PLHHTWSYQA LVHDVLDLGL NLVYVEDETA SAGARKKPKA
CDLDRNDRFW MTHKGSPFPT VAEAIQEELE SYRNSEEEIK RLKTSMGIEG ESDIAFSLVN
DTTARLTNAV NSLPQLMEKK RLIDMHTKIA TAILNFIKAR RLDSFFEIEE KVMSKQTLDR
PLLDLLRDGE FGQAEDKLRL YIIYFICAQQ LPESEQERLK EALQAAGCDL TALAYVQRWK
GIMNRSPSIS QATQYEGGGT KTVSMFTKLV SQGSSFVMEG VKNLVVKRHN LPVTKITEQV
MECRSNAETD DYLYLDPKLL KGGEVLPKNR APFQDAVVFM VGGGNYIEYQ NLVDFIKQKQ
TSNVQRRIIY GASTLTNARQ FLKELSALGG EIQSPTATS
