ID   SLY1_DROVI              Reviewed;         656 AA.
AC   O18637;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein sly1 homolog;
GN   Name=Slh;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8675012; DOI=10.1101/gad.10.10.1260;
RA   Merli C., Bergstrom D.E., Cygan J.A., Blackman R.K.;
RT   "Promoter specificity mediates the independent regulation of neighboring
RT   genes.";
RL   Genes Dev. 10:1260-1270(1996).
CC   -!- FUNCTION: Non-vital for development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U95037; AAB71530.1; -; Genomic_DNA.
DR   AlphaFoldDB; O18637; -.
DR   SMR; O18637; -.
DR   STRING; 7244.FBpp0238599; -.
DR   eggNOG; KOG1301; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IEA:EnsemblMetazoa.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Repeat.
FT   CHAIN           1..656
FT                   /note="Protein sly1 homolog"
FT                   /id="PRO_0000206301"
FT   REPEAT          85..121
FT                   /note="1"
FT                   /evidence="ECO:0000305"
FT   REPEAT          203..245
FT                   /note="2"
FT                   /evidence="ECO:0000305"
FT   REPEAT          419..456
FT                   /note="3"
FT                   /evidence="ECO:0000305"
FT   REPEAT          460..496
FT                   /note="4"
FT                   /evidence="ECO:0000305"
FT   REGION          85..496
FT                   /note="4 X approximate repeats"
SQ   SEQUENCE   656 AA;  74423 MW;  A4AF5EAA8E17DC4F CRC64;
     MLTLRERQIN AIKQMLNLNS QQPKAMAADA VWKILIYDRV GQDIISPIIS IKELRELGVT
     LHVQLHSDRD SIPDVPAVYF CLPTDENLDR IQQDFSNGLY DIYHLNFLAP ITRSKIENLA
     AAALHAGCVA NIHRVYDQYV NFISLEDDFF ILKHQQSDQL SYYAINRANT RDEEMEALMD
     SIVDSLFALF VTLGNVPIIR CPRNSAAEMV ARKLEKKLRE NLWDARANLF HMDATQAGGG
     VFSFQRPVLL LLDRNMDLAT PLHHTWSYQA LVHDVLDLGL NLVYVEDEGA RKKPKACDLD
     RNDRFWVTHK GSPFPTVAEA IQEELESYRN SEEEIKRLKT SMGIEGESDI AFSLVNDTTA
     MLTSAVNSLP QLMEKKRLID MHTKIATAIL NCIKARRLDS YFEIEEKIMS KQTLDKPLLE
     LLRDAEFGQP EDKLRLYIIY YICAQQLPEP ELERLREALQ SAGCDLTALA YVQRWKSIMN
     RSPSISQATQ YEGGGTRTVS MFTKLVSQGS SFVMEGVKNL VVKRHVNINL RLGSDRVKAK
     LIPNFLENLP VTKITEQVME CRSNAETDDY LYLAPKLLKG GDVLPKNRAP FQDAVVFMVG
     GGNYIEYQNL VDFIKQKQTS NVHRRIIYGG STLTNARQFL KELSALGGEI QTPTAS