ID   SLY1_ENCCU              Reviewed;         521 AA.
AC   Q8SS97;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=SEC1 family transport protein SLY1;
GN   Name=SLY1; OrderedLocusNames=ECU03_0900;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Involved in vesicular transport between the endoplasmic
CC       reticulum and the Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; AL590443; CAD26234.1; -; Genomic_DNA.
DR   RefSeq; NP_597599.1; NM_001040963.1.
DR   AlphaFoldDB; Q8SS97; -.
DR   SMR; Q8SS97; -.
DR   STRING; 284813.Q8SS97; -.
DR   GeneID; 858761; -.
DR   KEGG; ecu:ECU03_0900; -.
DR   VEuPathDB; MicrosporidiaDB:ECU03_0900; -.
DR   HOGENOM; CLU_016216_4_0_1; -.
DR   InParanoid; Q8SS97; -.
DR   OMA; DAHMSIC; -.
DR   OrthoDB; 917326at2759; -.
DR   Proteomes; UP000000819; Chromosome III.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..521
FT                   /note="SEC1 family transport protein SLY1"
FT                   /id="PRO_0000383110"
SQ   SEQUENCE   521 AA;  59195 MW;  503D5BCC01C615E6 CRC64;
     MLRELQKQRI KAFLVAPNNP WKILVLDSRT QQIIGPLMKV SELRECGITA HFLVTQERHP
     ISNTPAVYFV ESADGVLDDV LAELYSEYYL NFATSVTRGE IESLGLGLSE RGLGLRIRSV
     YDQFVDFIAL QDDMFTLGMK GSFIEMENPD TWRRMVMSVM SVFVTLGEVP FIVATDDDVT
     TQMARMLETK IRNTGVIKRG SKRPVLVLVS RSHDVITPVQ HVWSYSALMN DLFALESNKI
     TLKSGKVFDL DPQDELWRRN ANEYFPVVVE RVEKELLEYK KEMALRSIDE KTDKKVIQEA
     LDKAPELAKR NESVNAHISI CSEMVEMIKE RAIDDFYKVE KGGHTNQELI ELSEKGSDED
     VLRLAILLLN TKDFDLIDPL LRKRKIKSKA IEFFRRHGGT RSEKLGTLYS QVVTSLMGNV
     KKLLPVKEQT PISSLVETIY GDIKSQIYSG LRVFDSMGSK SIYASEISRL VVFGVGGGTY
     TELKTLKLLE ERIGVPIIYG STEILNAREF LRQVEGRMSL D