ID   SLY1_SCHPO              Reviewed;         639 AA.
AC   O74534;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Protein sly1;
GN   Name=sly1; ORFNames=SPCC74.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA20831.1; -; Genomic_DNA.
DR   PIR; T41585; T41585.
DR   RefSeq; NP_588374.1; NM_001023365.2.
DR   AlphaFoldDB; O74534; -.
DR   SMR; O74534; -.
DR   BioGRID; 275668; 3.
DR   STRING; 4896.SPCC74.01.1; -.
DR   iPTMnet; O74534; -.
DR   MaxQB; O74534; -.
DR   PaxDb; O74534; -.
DR   PRIDE; O74534; -.
DR   EnsemblFungi; SPCC74.01.1; SPCC74.01.1:pep; SPCC74.01.
DR   GeneID; 2539096; -.
DR   KEGG; spo:SPCC74.01; -.
DR   PomBase; SPCC74.01; sly1.
DR   VEuPathDB; FungiDB:SPCC74.01; -.
DR   eggNOG; KOG1301; Eukaryota.
DR   HOGENOM; CLU_016216_3_1_1; -.
DR   InParanoid; O74534; -.
DR   OMA; DRQLDNF; -.
DR   PhylomeDB; O74534; -.
DR   Reactome; R-SPO-204005; COPII-mediated vesicle transport.
DR   Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR   PRO; PR:O74534; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; ISS:PomBase.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..639
FT                   /note="Protein sly1"
FT                   /id="PRO_0000316617"
SQ   SEQUENCE   639 AA;  71665 MW;  BB8719284AC2ECB2 CRC64;
     MSIASVKTPS SLREAQIQSL EKLLNLNQDV NELESSPQHA SNFPIWKVLI FDKAGSETIS
     SVLRISDLRK HGVTVHMNIT SFRQPIADVP AIYFVQPTQE NIELIIEDLS KGLYESAYVC
     FSSTISRALL EQFAELASKT NTSHMIHQVY DQYLNYVVLE SDFFSLQLPK IFHTFHNPSS
     DEALINSRVQ DIVNGLFSVI VTLGTIPIIR CPQGSAAEMV AQKLNQRLKD HLMNTKDAFV
     SVNPKPRPIL ILLDRTVDLI PMINHSWTYQ ALIHDTLNMQ LNRITVESVD DGKMTKRFYD
     LDGNDFFWES NASKPFPKVA ENIDEELTRY KNDASEITRK SGVSSLEEVN VDAFADSTYL
     KSAVSLLPEL TARKQILDMH MNIATALLKA IQERHLDDFF QLEDNITGLN RSAILACINN
     KEQGTPEDKL RFFIIWYLSV DSVPASDLQA YEEALVNNGC TLEALNFVKR VREITKMTML
     ASSTTRPATG QTGDNLFRGF SSLSTRFTDR FKEAGIGGLE NIISGVRNLI PFRKDGTITS
     IVQSLMDPGS SPASKQTESY LLLDPKSARA ITVNNDPRAM NKRQTFSEAI VCVLGGGNYL
     EYGNLADWAR EQNPKKRIIY GSTDILSPSE FMEEMASLS