BICRL_MOUSE
ID BICRL_MOUSE Reviewed; 1074 AA.
AC Q8CHH5;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=BRD4-interacting chromatin-remodeling complex-associated protein-like {ECO:0000250|UniProtKB:Q6AI39};
GN Name=Bicral {ECO:0000250|UniProtKB:Q6AI39};
GN Synonyms=Gltscr1l {ECO:0000312|MGI:MGI:2673855},
GN Kiaa0240 {ECO:0000312|EMBL:BAC41403.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-1074.
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION IN THE GBAF COMPLEX.
RX PubMed=29374058; DOI=10.1074/jbc.ra117.001065;
RA Alpsoy A., Dykhuizen E.C.;
RT "Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog
RT GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.";
RL J. Biol. Chem. 293:3892-3903(2018).
CC -!- FUNCTION: Component of SWI/SNF chromatin remodeling subcomplex GBAF
CC that carries out key enzymatic activities, changing chromatin structure
CC by altering DNA-histone contacts within a nucleosome in an ATP-
CC dependent manner. {ECO:0000250|UniProtKB:Q6AI39}.
CC -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The
CC canonical complex contains a catalytic subunit (either
CC SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1,
CC ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47.
CC Other subunits specific to each of the complexes may also be present
CC permitting several possible combinations developmentally and tissue
CC specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at
CC least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF
CC subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53,
CC SMARCC1/BAF155, and SMARCD1/BAF60A. {ECO:0000269|PubMed:29374058}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK029927; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK029927; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB093219; BAC41403.1; -; mRNA.
DR CCDS; CCDS50126.1; -.
DR RefSeq; NP_001093922.1; NM_001100452.1.
DR RefSeq; XP_006524039.1; XM_006523976.3.
DR RefSeq; XP_006524043.1; XM_006523980.3.
DR RefSeq; XP_006524044.1; XM_006523981.3.
DR RefSeq; XP_017172866.1; XM_017317377.1.
DR AlphaFoldDB; Q8CHH5; -.
DR ComplexPortal; CPX-4204; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant.
DR ComplexPortal; CPX-4222; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant.
DR ComplexPortal; CPX-4228; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant.
DR ComplexPortal; CPX-4230; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant.
DR STRING; 10090.ENSMUSP00000044833; -.
DR iPTMnet; Q8CHH5; -.
DR PhosphoSitePlus; Q8CHH5; -.
DR EPD; Q8CHH5; -.
DR MaxQB; Q8CHH5; -.
DR PaxDb; Q8CHH5; -.
DR PRIDE; Q8CHH5; -.
DR ProteomicsDB; 273688; -.
DR Antibodypedia; 30175; 23 antibodies from 8 providers.
DR Ensembl; ENSMUST00000040624; ENSMUSP00000044833; ENSMUSG00000036568.
DR Ensembl; ENSMUST00000233537; ENSMUSP00000156590; ENSMUSG00000036568.
DR GeneID; 210982; -.
DR KEGG; mmu:210982; -.
DR UCSC; uc008cul.2; mouse.
DR CTD; 23506; -.
DR MGI; MGI:2673855; Bicral.
DR VEuPathDB; HostDB:ENSMUSG00000036568; -.
DR eggNOG; ENOG502QPQ9; Eukaryota.
DR GeneTree; ENSGT00940000159766; -.
DR HOGENOM; CLU_011632_0_0_1; -.
DR InParanoid; Q8CHH5; -.
DR OMA; DQFHPVP; -.
DR OrthoDB; 352636at2759; -.
DR PhylomeDB; Q8CHH5; -.
DR TreeFam; TF335495; -.
DR BioGRID-ORCS; 210982; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Bicral; mouse.
DR PRO; PR:Q8CHH5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8CHH5; protein.
DR Bgee; ENSMUSG00000036568; Expressed in superior cervical ganglion and 226 other tissues.
DR ExpressionAtlas; Q8CHH5; baseline and differential.
DR Genevisible; Q8CHH5; MM.
DR GO; GO:0000785; C:chromatin; IC:ComplexPortal.
DR GO; GO:0140288; C:GBAF complex; IC:ComplexPortal.
DR GO; GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
DR GO; GO:0006338; P:chromatin remodeling; IC:ComplexPortal.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IC:ComplexPortal.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IC:ComplexPortal.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IC:ComplexPortal.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IC:ComplexPortal.
DR InterPro; IPR038842; BICRA.
DR InterPro; IPR015671; GSCR1_dom.
DR PANTHER; PTHR15572:SF2; PTHR15572:SF2; 1.
DR Pfam; PF15249; GLTSCR1; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1074
FT /note="BRD4-interacting chromatin-remodeling complex-
FT associated protein-like"
FT /id="PRO_0000248603"
FT REGION 542..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 621
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AI39"
FT MOD_RES 976
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AI39"
SQ SEQUENCE 1074 AA; 114350 MW; 49F7BFC67AA46655 CRC64;
MDDDDDSCLL DLIGDPQALN YFLHGPSSKS GSDDVTNAGY SAANSNSIFA NSTNADPKSA
LKGVSDQLGE GPSDGLPLAS SLQFLEDELE SSPLPDLSED QPFDILQKSL QEANITEQTL
AEEAYLDASI GSSQQFAQAQ LHPSSSASFT QASNVSNYSG QTLQPIGVTH VPVGASFASN
TVGVQHGFMQ HVGISVPSQH LPNSSQISGS GQIQLIGSFG NQPSMMTINN LDGSQIILKG
SGQQAPSNVS GGLLVHRQTP NGNSLFGNST SSPVAQPVTV PFNSTNFQAS LPVHNIIIQR
GLAPNSNKVP INIQPKPVQM GQQSAYNVNN LGIQQHHAQQ GISFAPTSSP QGSVVGPHMS
VNIVNQQNTR KPVTSQAVSG TGGSIVIHSP MGQPHTPQSQ FLIPTSLSVS SNSVHHVQAI
NGQLLQTQPS QLISGQVASE HVMLNRNSSN MLRTNQPYSG QMLNNQNTAV QLVSGQTFAT
SGSPVIVNHA SPQIVGGQMP LQQASPTVLH LSPGQSSVSQ GRPGFATMPA VSGMAGPARF
PAVSSASTAH PTLGPTVQSG APGSNFTGDQ LTQANRTPAP VSVSHRLPVS ASKSPSTLSN
TPGTQQQFFC QAQKKCLNQT SPIPTSKTTD GLRPSQIPGL LSTALPGQDS GSKIMPATLG
ATQAQPESSV GSSPSQTAVQ VDSHPGQKRP AAKQLTKGAF ILQQLQRDQA HAVTPDKSQF
RSLNDTVQRL LSYHVCQGSM PTEEDLRQVD NEFEEVATQL LKRTQAMLNK YRFLLLEDAM
RINPSAEMVM IDRMFNQEER ASLSRDKRLA LVDPEGFQAD FCCSFKLDEA VPETPLDRSD
QHRSKTSSLH QVPRAQSRDR AKPGMAEATN HDQFHLVPNH IVVSAEGNIS KKSEGHSRTL
KFDRGVLGQY RGPPEDKGGR RDPAKVSRCS PGPEGHRKSL PRPDHGSESK LPGVLASSHM
EMPCLDSFQD KALRNSPKNE VLHTDIMKGS GEPQPDLQLT KSLEKTFKNI LELKNSGRPP
SDPTASGAAD LDFPSFSPMA SQENCLEKFI PDHSEGVVET DSILEAAVNS ILEC
