ID   BID_CHICK               Reviewed;         193 AA.
AC   Q8JGM8; Q5ZL87;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=BH3-interacting domain death agonist;
GN   Name=BID; ORFNames=RCJMB04_7d15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bridgham J.T., Johnson A.L.;
RT   "BID expression in the hen ovary.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Induces caspases and apoptosis. Counters the protective
CC       effect of Bcl-2 (By similarity). {ECO:0000250|UniProtKB:P70444}.
CC   -!- SUBUNIT: Forms heterodimers either with the pro-apoptotic protein BAX
CC       or the anti-apoptotic protein Bcl-2. {ECO:0000250|UniProtKB:P70444}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70444}.
CC       Mitochondrion outer membrane {ECO:0000250|UniProtKB:P55957}.
CC   -!- DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for
CC       their pro-apoptotic activity and for their interaction with anti-
CC       apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2
CC       family.
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DR   EMBL; AY112660; AAM48284.1; -; mRNA.
DR   EMBL; AJ719847; CAG31506.1; -; mRNA.
DR   RefSeq; NP_989883.2; NM_204552.2.
DR   RefSeq; XP_015139899.1; XM_015284413.1.
DR   AlphaFoldDB; Q8JGM8; -.
DR   SMR; Q8JGM8; -.
DR   STRING; 9031.ENSGALP00000021253; -.
DR   PaxDb; Q8JGM8; -.
DR   GeneID; 395236; -.
DR   KEGG; gga:395236; -.
DR   CTD; 637; -.
DR   VEuPathDB; HostDB:geneid_395236; -.
DR   eggNOG; ENOG502SAN7; Eukaryota.
DR   HOGENOM; CLU_090524_0_0_1; -.
DR   InParanoid; Q8JGM8; -.
DR   OrthoDB; 1218538at2759; -.
DR   PhylomeDB; Q8JGM8; -.
DR   TreeFam; TF102047; -.
DR   PRO; PR:Q8JGM8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0008637; P:apoptotic mitochondrial changes; IBA:GO_Central.
DR   GO; GO:0097284; P:hepatocyte apoptotic process; ISS:UniProtKB.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR010479; BID.
DR   PANTHER; PTHR35447; PTHR35447; 1.
DR   Pfam; PF06393; BID; 1.
DR   PIRSF; PIRSF038018; BID; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Reference proteome.
FT   CHAIN           1..193
FT                   /note="BH3-interacting domain death agonist"
FT                   /id="PRO_0000223373"
FT   MOTIF           87..101
FT                   /note="BH3"
FT                   /evidence="ECO:0000250|UniProtKB:P70444"
SQ   SEQUENCE   193 AA;  21678 MW;  BB881DBC5079214B CRC64;
     MEQDIYSNGS DHMERMLLFA FLAESSGCEF QEQLPSLQSQ GVLCSVKDAL CYDSDGELQT
     DGNRSGHLQN GELVPDPEVN EAIVRTIAAQ LAEIGDQLDK QIKAKVVNDL VQHFLNENLP
     REEITRCLSQ AVEGLARAIP SDLEQEKAML VLAMLLTKKV ANQMPSLLQR VFSTTVNYIS
     QHFHNYIVRM LRE