ID   SLYA_PHOLL              Reviewed;         143 AA.
AC   Q8KM02;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
GN   Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; Synonyms=hor, rap;
GN   OrderedLocusNames=plu2600;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=12147472; DOI=10.1128/aem.68.8.3780-3789.2002;
RA   Derzelle S., Duchaud E., Kunst F., Danchin A., Bertin P.;
RT   "Identification, characterization and regulation of a cluster of genes
RT   involved in carbapenem biosynthesis in Photorhabdus luminescens.";
RL   Appl. Environ. Microbiol. 68:3780-3789(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Transcription regulator that can specifically activate or
CC       repress expression of target genes. Regulates the cpm operon, which
CC       contains cpmA, cpmB, cpmC, cpmD, cpmE, cpmF, cpmG and cpmH, involved in
CC       carbapenem-like antibiotic production. {ECO:0000255|HAMAP-
CC       Rule:MF_01819, ECO:0000269|PubMed:12147472}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC   -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01819}.
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DR   EMBL; AJ457089; CAD29771.1; -; Genomic_DNA.
DR   EMBL; BX571867; CAE14974.1; -; Genomic_DNA.
DR   RefSeq; WP_011146822.1; NC_005126.1.
DR   AlphaFoldDB; Q8KM02; -.
DR   SMR; Q8KM02; -.
DR   STRING; 243265.plu2600; -.
DR   EnsemblBacteria; CAE14974; CAE14974; plu2600.
DR   GeneID; 24166061; -.
DR   KEGG; plu:plu2600; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_083287_18_2_6; -.
DR   OMA; CSNDRRA; -.
DR   OrthoDB; 1744037at2; -.
DR   BioCyc; PLUM243265:PLU_RS12870-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01819; HTH_type_SlyA; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023071; Tscrpt_reg_SlyA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Antibiotic biosynthesis; DNA-binding; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..143
FT                   /note="Transcriptional regulator SlyA"
FT                   /id="PRO_0000054390"
FT   DOMAIN          2..135
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT   DNA_BIND        49..72
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
SQ   SEQUENCE   143 AA;  16474 MW;  D1F8CB713A0C03FD CRC64;
     MESTLGSDLA RLVRIWRALI DYRLKPLELT QTHWVTLYNI SRLPQEQSQI QLAKAIGIEQ
     PSLVRTLDQL EEKKLITRHT CANDRRAKRI KLTEDSASVI RELDGVIEST RNEILGGISR
     EELAFLSTLV QKLEQNIIQL QSR