ID   SLYA_SALCH              Reviewed;         144 AA.
AC   P61090; O54521; Q57PJ3;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
GN   Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; OrderedLocusNames=SCH_1462;
OS   Salmonella choleraesuis (strain SC-B67).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RF-1;
RX   PubMed=10385201; DOI=10.1111/j.1348-0421.1999.tb02415.x;
RA   Kawakami T., Kaneko A., Okada N., Imajoh-Ohmi S., Nonaka T., Matsui H.,
RA   Kawahara K., Danbara H.;
RT   "TTG as the initiation codon of Salmonella slyA, a gene required for
RT   survival within macrophages.";
RL   Microbiol. Immunol. 43:351-357(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CH12440 / Serotype C1;
RA   Chang G., Ho K.C.;
RT   "The slyA gene of Salmonella choleraesuis.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
RN   [4]
RP   FUNCTION.
RX   PubMed=11939575; DOI=10.1111/j.1348-0421.2002.tb02666.x;
RA   Kaneko A., Mita M., Sekiya K., Matsui H., Kawahara K., Danbara H.;
RT   "Association of a regulatory gene, slyA with a mouse virulence of
RT   Salmonella serovar Choleraesuis.";
RL   Microbiol. Immunol. 46:109-113(2002).
CC   -!- FUNCTION: Transcription regulator that can specifically activate or
CC       repress expression of target genes. Required to activate expression of
CC       virulent genes. {ECO:0000255|HAMAP-Rule:MF_01819,
CC       ECO:0000269|PubMed:11939575}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC   -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01819}.
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DR   EMBL; AB010776; BAA24581.1; -; Genomic_DNA.
DR   EMBL; AF242419; AAL55673.1; -; Genomic_DNA.
DR   EMBL; AE017220; AAX65368.1; -; Genomic_DNA.
DR   RefSeq; WP_000445639.1; NC_006905.1.
DR   AlphaFoldDB; P61090; -.
DR   SMR; P61090; -.
DR   EnsemblBacteria; AAX65368; AAX65368; SCH_1462.
DR   KEGG; sec:SCH_1462; -.
DR   HOGENOM; CLU_083287_18_2_6; -.
DR   OMA; CSNDRRA; -.
DR   Proteomes; UP000000538; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01819; HTH_type_SlyA; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR023071; Tscrpt_reg_SlyA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..144
FT                   /note="Transcriptional regulator SlyA"
FT                   /id="PRO_0000054391"
FT   DOMAIN          2..135
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT   DNA_BIND        49..72
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
SQ   SEQUENCE   144 AA;  16448 MW;  4647F7704F2D78DE CRC64;
     MESPLGSDLA RLVRIWRALI DHRLKPLELT QTHWVTLHNI HQLPPDQSQI QLAKAIGIEQ
     PSLVRTLDQL EDKGLISRQT CASDRRAKRI KLTEKAEPLI AEMEEVIHKT RGEILAGISS
     EEIELLIKLV AKLEHNIMEL HSHD