ID   SLYA_YEREN              Reviewed;         143 AA.
AC   Q9S3W0;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
DE   AltName: Full=Regulator of virulence protein A;
GN   Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; Synonyms=rovA;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=JB580v / Serotype O:8;
RX   PubMed=10672189; DOI=10.1046/j.1365-2958.2000.01740.x;
RA   Revell P.A., Miller V.L.;
RT   "A chromosomally encoded regulator is required for expression of the
RT   Yersinia enterocolitica inv gene and for virulence.";
RL   Mol. Microbiol. 35:677-685(2000).
RN   [2]
RP   FUNCTION.
RX   PubMed=12761136; DOI=10.1128/iai.71.6.3512-3520.2003;
RA   Dube P.H., Handley S.A., Revell P.A., Miller V.L.;
RT   "The rovA mutant of Yersinia enterocolitica displays differential degrees
RT   of virulence depending on the route of infection.";
RL   Infect. Immun. 71:3512-3520(2003).
CC   -!- FUNCTION: Transcription regulator that can specifically activate or
CC       repress expression of target genes. Required for expression of the
CC       virulence gene inv. Important for the regulation of genes that
CC       influence the early stages of infection that occur in the Peyer plaque.
CC       {ECO:0000255|HAMAP-Rule:MF_01819, ECO:0000269|PubMed:10672189,
CC       ECO:0000269|PubMed:12761136}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC   -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01819}.
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DR   EMBL; AF171097; AAD51968.1; -; Genomic_DNA.
DR   RefSeq; WP_004706617.1; NZ_UHIX01000001.1.
DR   AlphaFoldDB; Q9S3W0; -.
DR   SMR; Q9S3W0; -.
DR   STRING; 1443113.LC20_02898; -.
DR   GeneID; 67418214; -.
DR   eggNOG; COG1846; Bacteria.
DR   OrthoDB; 1744037at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01819; HTH_type_SlyA; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR023071; Tscrpt_reg_SlyA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..143
FT                   /note="Transcriptional regulator SlyA"
FT                   /id="PRO_0000054397"
FT   DOMAIN          2..135
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT   DNA_BIND        49..72
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
SQ   SEQUENCE   143 AA;  16240 MW;  462601E99921F502 CRC64;
     MESTLGSDLA RLVRVWRALI DHRLKPLELT QTHWVTLHNI NRLPPEQSQI QLAKAIGIEQ
     PSLVRTLDQL EEKGLITRHT CANDRRAKRI KLTEQSSPII EQVDGVICST RKEILGGISP
     DEIELLSGLI DKLERNIIQL QSK